Cardiology studies Flashcards
Courage study
N Engl J Med 2007 Apr 12
2287 patients with stable CAD class IV angina stabilized medical
PCI (with BMS) vs medical therapy
No difference in composite all cause mortality and non-fatal MI
No difference in ACS hospitalization
What are ECH signs of right ventricular hypertrophy
R in V1 + S in V6 is > 11mm
Anterior T wave inversion
S wave = 5 mm
R wave = 14 mm
11150823-ITA
What are ECG findings in pericarditis
Global concave upwards ST elevation
Inverted T waves
Pseudonomalisation of the ST segments with T wave flattening
Normal ECG
What are features of Right bundle Branch
Wide QRS
RsR or rR in V1 and Q waves in V6
- so think RBBB is “rabbit ears” in the V1 lead
What is feature of LBBB
Left axis deviation
QRS < 120 ms (incomplete bundle branch
look for rabbit ears in the V6
What is Plato study
PLATO found that ticagrelor had better mortality rates than clopidogrel (9.8% vs. 11.7%, p<0.001) in treating patients with acute coronary syndrome.
Patients given ticagrelor were less likely to die from vascular causes, heart attack, or stroke but had greater chances of non-lethal bleeding (16.1% vs. 14.6%, p=0.0084),
higher rate of major bleeding not related to coronary-artery bypass grafting (4.5% vs. 3.8%, P=0.03), including more instances of fatal intracranial bleeding.
Rates of major bleeding were not different. Discontinuation of the study drug due to adverse events occurred more frequently with ticagrelor than with clopidogrel (in 7.4% of patients vs. 6.0%, P<0.001
RE-LY study
N Engl J Med 2009 Sep 2009
18 113 patients
AF > 75 years old; Dabigtran vs warfarin with a median follow up for 2 years
150 mg of Dabigatran significantly lower rate of stroke and embolism similar rate of major bleeding 110 mg of Dabigatran similar rate of stroke and embolism lower rates of major bleeding Both doses significantly reduced risk of intracranial hemorrhage increased risk of GI bleeding dyspepsi most common side effect
