Atrial septal defects Flashcards
List 3 main types of ASD
Ostium Secundum (80%) Ostium Primum (10%) Sinus venosus (10%)
Other 3 types
Common single atrium
Unroofed coronary sinus
Patent foramen ovale
What is Ostium Secundum
Confined to the region of the fossa ovalis
Result from a deficiency of the septum primum to adequately close the foramen ovale
Defect size ranges from a pinhole to a larger
What is Sinus venosus
Typically at junction between the SVC and RA
Located in posterior in the septum and above the superior limbic band (the superior rim of the fossa ovalis
*common association with anomalous drainage of the RSPV
RSPV tends to enter the LA at the junction of the SVC and RA along the right margin of the ASD.
Rarely ASD can occur adjacent to the IVC and be associated with anomlaous RIPV drainage
What is Ostium Primum
Crescent-shaped defect in inferior septum immediately adjacent to atrioventricular valves
Also considered a partial/incomplete AV canal defect
Frequently asso with cleft in anterior MV leaflet (+/- MR)
What is unroofed coronary sinus
Direct communication between the coronary sinus and the LA
Blood drains from LA through CS into the RA
No actual opening in the septum
Frequently a left superior vena cava draining into coronary sinus (or sometimes LA)
Pathophysiolgy of ASD
Degree of shunting dependent on ASD size and ventricular compliance
Normally PL > PR and RV more compliant so you get Left to Right shunt
Causes RV dilation and excessive pulmonary flow
Generally not cynaotic (only if common atrium and unroofed CS)
What is clinical course
If significant develop RV dysfunction, Pulmonary hypertension, CHF, and usually death (often early in 3rd decade)
Defects < 4 mm will usually close
Defects > 8 mm are unlikely to close
Closure of any ASD after age 4 is unlikely
Isolated ASD is not a risk factor for IE
List physical signs of ASD
Audible murmur is that of physiologic pulmonic stenosis (increased flow over PV
ECH will show RVH, RAD
ECHO is needed
10% need a cath to look for anomalies, document pressures
Common to have a 10 to 30mmHg gradient over PV
What are the CCS 2009 guidelines for closure of ASD
Should be closed in the presence of hemodynamically significant ASD with or without symptoms
A large ASD is greater then 38 mm and this should be closed surgically
If pulmonary hypertension is present and reversible
Qp:QS shunt of 1.5
What are the European Class I indication for close of ASD
1) Patients with significant shunt (signs of RV overload) and a PVR < 5 should undergo closure regardless of symptoms
2) Device closure is the method of choice
IIa
1) Regardless of size with suspicision of pardoxical embolism
What are indications to close ASD
Physical symptoms of CHF
Qp/Qs > 1.5 to 1. Almost all will have this if they physical signs or fixed S2
Close ASD prior to child starting school
How is pulmonary vasculature overload tolerated
Usually pretty well (for many yers)
25% develop PHTN (with PAS > 30mmHg)
Can still develop obstructive pulmonary vascular disease
Increased PVR by 10%
Can develop Eisenmenger’s syndrome
Most common cause for late mortality is CHF and arrhythmias
What is most common complication of transcatheter closing of ASD
Most common complication with device closure are malposition and dislocation
Good results when patients are selected appropriately
only adequate when there is an achoring rim
What are results of Ostium secundom defect closure
Excellent
Very low peri-operative MandM
Long-term survival is equal to that of age-matched cohort
Very rare to need re-operation
What are oucomes for Sinus venosus defects
SVC and RSPC stenosis is < 10%
Sinus dysfunction is about 7%
rare to need a PPM