patches Flashcards

1
Q

is transcutaneous local or systemic

A

local

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2
Q

is transdermal local or systemic

A

systemic

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3
Q

durogesic active drug

A

fentanyl

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4
Q

durogesic transdermal or not

A

transdermal

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5
Q

voltatrol or transdermal or transcutaneous

A

transcutaneous

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6
Q

voltarol active drug

A

diclofenac

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7
Q

advantages transdermal

A

Avoids hepatic first-pass metabolism (but skin could also metabolise drugs). • Non-invasive. • Extended release. • Readily applied and removable

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8
Q

disadvantages of transdermal

A

-

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9
Q

reservoir and matrix contains drug or controls drug release

A

contains drug

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10
Q

is rate limiting membrane matrix containing drug or controls drug release

A

controls drug release

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11
Q

function of polyacrylates

A

Adhesive

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12
Q

function of Polyester/ethylene vinyl acetate copolymer film

A

Backing film

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13
Q

function of Siliconized polyester

A

Proctetive release liner

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14
Q

function of Dipropylene glycol

A

Solvent

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15
Q

function of Hydroxylpropyl cellulose

A

matrix

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16
Q

function of dimeticone

17
Q

function of silicone

18
Q

function of EVA

A

rate- controlling membrane

19
Q

function of Polyethelene terephthalate film

A

backing film

20
Q

function of fluoropolymer-coated polyester film

A

protective release liner

21
Q

in stratum corneum is it lipophillic

A

lipophillic

22
Q

the stratum corneum is the ……………………. diffusion barrier

A

rate-limiting

23
Q

what are the different pathways

A

partitioning

diffusion

24
Q

which pathway is in the same medium

25
in transcutaneous you want the drug to be localised in the tissue ........... the stratum corneum
below
26
in transcellular what you want with the drug
to be carried away
27
give me the equation for transdermal drug absorption kinetics
J= (DK/h)A triangle= KpA triange C
28
give me the equation for skin permeability
logKp= 0.71 . logP -0.0061MW- 6.3
29
what does potts and guys equation do
- Predict skin permeability from drug properties - Molecular weight - Lipophilicity