patches

Question 1

is transcutaneous local or systemic

Answer 1

local

Question 2

is transdermal local or systemic

Answer 2

systemic

Question 3

durogesic active drug

Answer 3

fentanyl

Question 4

durogesic transdermal or not

Answer 4

transdermal

Question 5

voltatrol or transdermal or transcutaneous

Answer 5

transcutaneous

Question 6

voltarol active drug

Answer 6

diclofenac

Question 7

advantages transdermal

Answer 7

Avoids hepatic first-pass metabolism (but skin could also metabolise drugs). • Non-invasive. • Extended release. • Readily applied and removable

Question 8

disadvantages of transdermal

Answer 8

-

Question 9

reservoir and matrix contains drug or controls drug release

Answer 9

contains drug

Question 10

is rate limiting membrane matrix containing drug or controls drug release

Answer 10

controls drug release

Question 11

function of polyacrylates

Answer 11

Adhesive

Question 12

function of Polyester/ethylene vinyl acetate copolymer film

Answer 12

Backing film

Question 13

function of Siliconized polyester

Answer 13

Proctetive release liner

Question 14

function of Dipropylene glycol

Answer 14

Solvent

Question 15

function of Hydroxylpropyl cellulose

Answer 15

matrix

Question 16

function of dimeticone

Answer 16

matrix

Question 17

function of silicone

Answer 17

adhesive

Question 18

function of EVA

Answer 18

rate- controlling membrane

Question 19

function of Polyethelene terephthalate film

Answer 19

backing film

Question 20

function of fluoropolymer-coated polyester film

Answer 20

protective release liner

Question 21

in stratum corneum is it lipophillic

Answer 21

lipophillic

Question 22

the stratum corneum is the ……………………. diffusion barrier

Answer 22

rate-limiting

Question 23

what are the different pathways

Answer 23

partitioning

diffusion

Question 24

which pathway is in the same medium

Answer 24

diffusion

Question 25

in transcutaneous you want the drug to be localised in the tissue ……….. the stratum corneum

Answer 25

below

Question 26

in transcellular what you want with the drug

Answer 26

to be carried away

Question 27

give me the equation for transdermal drug absorption kinetics

Answer 27

J= (DK/h)A triangle= KpA triange C

Question 28

give me the equation for skin permeability

Answer 28

logKp= 0.71 . logP -0.0061MW- 6.3

Question 29

what does potts and guys equation do

Answer 29

• Predict skin permeability from drug properties
• Molecular weight
• Lipophilicity