Female Sex Hormones Flashcards
what causes the gonadal cortex to become an ovary?
the absence of SRY protein and under the influence of female-specific genes
what effect does a lack of testosterone have on the Wolffian duct?
it causes it to degenerate
what effect does an absence of anti-mullerian hormone have on the mullerian duct?
allows the mullerian duct to become the Fallopian tube, uterus and upper parts of the vagina
explain the process of gametogenesis?
- germ cells duplicate through mitosis
2. then they form gametes with half the chromosome by meiosis
what does the ovary do?
produces sex hormones and germ cells
what hormones are used to control reproduction?
GnRH, FSH and LH
what does Theca do?
synthesises androgens under the influence of LH
what does Granulosa cells do?
release AMH and aromatase under the influence of FSH
when does estrone (E1) ovarian steroid hormone increase in levels?
post-menopause
when does estriol ovarian steroid hormone (E3) increase in levels?
during pregnancy
where are estrogens C18 more commonly release from?
Granulosa cells
where are Progestagens C21 more commonly released from?
Corpus Luteum
where are androgens C19 more commonly released from?
Theca
how does the oestrogen receptor (ER) work?
- it is a dimeric nuclear protein which binds to DNA and controls gene expression
- The estrogen:ER complex binds to specific DNA sequences called a hormone response element to activate the transcription of target genes.
what are the roles of estrogen?
- develop and regulate the female reproductive system and secondary sex characteristics
- provide hormonal timing for ovulation
- matures germ cells
- develops tissues needed for blastocyst implantation
- establishes the milieu required for pregnancy maintenance
- provides hormones needed for parturition and lactation