bDMARDS and tsDMARDS Flashcards
1
Q
describe anti-tnf agent infliximab
A
humanised anti-TNF mouse monoclonal ab
2
Q
describe anti tbf agent etanercept
A
recombinant soluble anti-TNF receptor
3
Q
describe anti tnf agent adalimumab
A
fully human anti-TNF monoclonal ab
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4
Q
name anti tnf agents certolizumab
A
PEGylated anti-TNF
5
Q
describe anti tnf agent golimumab
A
fully human anti-TNF monoclonal ab
6
Q
risks of anti- tnf therapy
A
Infection Pyogenic sepsis, especially dissemination Reactivation of latent infection e.g. TB Autoimmune disease Induction of ANA & frank lupus Demyelination Cancer Increased spread & recurrence of tumour e.g. melanoma
7
Q
name the biologics which target 3 different cytokines in RA
A
TNF
IL-6
IL-1
