Parkinson's Disease Flashcards
1
Q
What is Parkinson’s Disease?
A
Neurodegenrative disorder resulting from degeneration of dopamine producing neurones in the basal ganglia
2
Q
What is the role of the basal ganglia?
A
- Regulate planning, initiation & termination of movement
- Regulates muscle tone
- Controls subconscious & contraction of skeletal muscle
3
Q
What is the main source of dopamine?
A
Substance Nigra
4
Q
Which pathway promotes movement?
A
Direct
5
Q
Which pathway inhibits movement?
A
Indirect
6
Q
What is dopamines effect on both pathways?
A
It excites direct & inhibits indirect
So with a lack of dopamine there is a lack of excitation of direct and a lack of inhibition of indirect causing an overall lack of movement
7
Q
State some clinical features of PD
A
Slow or no movement
Resting tremor in fingers
Rigidity
Difficulty initiating movement
8
Q
State some other secondary clinical features
A
Shuffle Loss of facial expression Monotone speech Micrographia Sleep disorder Problems swallowing Depression/anxiety
9
Q
State some medication.
A
Sinemet, madopar act as dopamine replacement
