Papers Laying Around

Question 1

What are the dental features of hypophosphatasia?

2 features

Answer 1

• Premature tooth loss

- Periodontal disease

Question 2

What are the muscular symptoms of hypophosphatasia?

4 symptoms

Answer 2

• Weakness
• Chronic pain
• Waddling Gait
• Delayed or missed motor milestones

Question 3

What are the renal symptoms of hypophosphatasia?

3 symptoms

Answer 3

• Nephrocalcinosis
• Hypercalciuria
• Severe damage

Question 4

What are the respiratory symptoms of hypophosphatasia?

2 symptoms

Answer 4

• Pulmonary insufficiency

- Respiratory failure

Question 5

What are the rheumatologic symptoms of hypophosphatasia?

3 symptoms

Answer 5

• Chondrocalcinosis
• Pseudogout
• Osteoarthropathy

Question 6

What are the neurologic symptoms of hypophosphatasia?

2 symptoms

Answer 6

• Seizures

- Increased intra-cranial pressure

Question 7

Is the normal range of alkaline phosphatase activity higher in children or adults and why?

Answer 7

Higher in children because of skeletal growth.

Question 8

What two tests are used to confirm hypophosphatasia?

Answer 8

• Serum PLP (vitamin B6)

- Urinary PEA

Question 9

What happens to serum PLP (vitamin B6) in a patient has hypophosphatasia?

Answer 9

It is elevated.

Question 10

What are the skeletal features of hypophosphatasia?

6 features

Answer 10

• Rickets
• Short Stature
• Osteomalacia
• Osteopenia
• Non-healing fractures
• Craniosynostosis