Journals And Endocrine News

Question 0

What could low kisspeptin levels in early pregnancy predict?

Answer 0

Miscarriages

Question 1

What happens to insulin sensitivity in growth hormone receptor deficiency?

Answer 1

Increased insulin sensitivity that protects against diabetes and deceases cancer risks.

Question 2

What is IDegLira?

Answer 2

Combination of degludec and liraglutide.

Question 3

Does intensive glucose control after coronary bypass grafting reduce complications?

Answer 3

No.

Targets of 100 - 140 mg/dL were no better than targets of 140 - 180 mg/dL.

Question 4

What kind of drug is Belviq (lorcaserin)?

Answer 4

Weight loss drug.

Question 5

What is the mechanism of action of lenvatinib?

Answer 5

Multi-tyrosine kinase inhibitor

Question 6

Non-alcoholic fatty liver disease is strongly linked to increased incidence of chronic kidney disease.

True or false?

Answer 6

True

Question 7

How many families of thyroid hormone receptors are there, through which thyroid hormone function is meditated?

Answer 7

2

Question 8

Which one is the prohormone -

T3 or T4?

Answer 8

T4

Question 9

Does tight blood glucose control slow down the progression of diabetic neuropathy?

Answer 9

In type 1 diabetes but not type 2 diabetes.

Question 10

Name two studies that show that tight glycemic control in type 1 diabetes may limit the progression of diabetic neuropathy?

Answer 10

DCCT

EDIC

Question 11

Name four studies/trials that show tight glycemic control does not affect neuropathy in type 2 diabetes.

Answer 11

UKPDS
ACCORD
VADT
ADVANCE

Question 12

Which thyroid hormone receptor is a non-hormone-binding variant protein?

Answer 12

(TR) alpha 2

Question 13

Which gene is affected in thyroid hormone resistance syndrome?

Answer 13

Thyroid hormone receptor alpha gene

Question 14

Familial hyperchylomicronemia.

Frederickson hyperlipoproteinemia phenotype?

Answer 14

Type 1

Question 15

Familial hypercholesterolemia.

Fredrickson hyperlipoproteinemia phenotype?

Answer 15

Type 2A

Question 16

Combined hyperlipoproteinemia.

Frederickson hyperlipoproteinemia phenotype?

Answer 16

Type 2B

Question 17

Dysbetalipoproteinemia.

Fredrickson hyperlipoprotemia phenotype?

Answer 17

Type 3

Question 18

Primary or simple hypertriglyceridemia.

Fredrickson hyperlipoprotemia phenotype?

Answer 18

Type 4

Question 19

Mixed hypertriglyceridemia.

Fredrickson hyperlipoprotemia phenotype?

Answer 19

Type 5

Question 20

What is the main lipid change in type 1 hyperlipoprotemia?

Answer 20

Increased triglycerides.

Question 21

What is the main lipid change in type 2B hyperlipoprotemia?

Answer 21

Increased total cholesterol.

Question 22

What is the main lipid change in type 2B hyperlipoprotemia?

Answer 22

Increased total cholesterol and increased triglycerides.

Question 23

What is the main lipid change in type 3 hyperlipoprotemia?

Answer 23

Increased total cholesterol and increased triglycerides.

Question 24

What is the main lipid change in type 4 hyperlipoprotemia?

Answer 24

Increased triglycerides.

Question 25

What is the main lipid change in type 5 hyperlipoprotemia?

Answer 25

Increased total cholesterol and increased triglycerides.

Question 26

What is the primary lipoprotein change in type 1 hyperlipoprotemia?

Answer 26

Increased chylomicrons.

Question 27

What is the primary lipoprotein change in type 2A hyperlipoprotemia?

Answer 27

Increased LDL

Question 28

What is the primary lipoprotein change in type 2B hyperlipoprotemia?

Answer 28

Increased VLDL and increased LDL.

Question 29

What is the primary lipoprotein change in type 3 hyperlipoprotemia?

Answer 29

Increased IDL

Question 30

What is the primary lipoprotein change in type 4 hyperlipoprotemia?

Answer 30

Increased VLDL.

Question 31

What is the primary lipoprotein change in type 5 hyperlipoprotemia?

Answer 31

Increased VLDL and increased chylomicrons.

Question 32

What do LDL receptors in the liver do?

Answer 32

Remove LDL Cholesterol from circulation.

Question 33

What does PCSK9 do to LDL receptors?

Answer 33

Binds to them promoting their degradation.

Question 34

What does PCSK9 do to the LDL cholesterol levels?

Answer 34

Increases them

Question 35

PCOS involves a degree of low level inflammation. True or false?

Answer 35

True

Question 36

Is pregnancy a low level inflammation state?

Answer 36

Yes

Question 37

Should you hold back when treating thyroid storm?

Answer 37

No - hit it with everything you have.

Question 38

Is the prevalence of congestive heart failure in type 2 diabetes mellitus more than that of the general population?

Answer 38

Yes

Question 39

The risk of cardiovascular disease is increased by ____ times in patients with type 1 diabetes mellitus.

Answer 39

10

Question 40

Levonorgestrel 1.5 mg (emergency contraception pill) loses it potency in women over what weight?

Answer 40

165 lbs

Question 41

Levonorgestrel 1.5 mg (emergency contraceptive pill) does not work in women above what weight?

Answer 41

175 lbs

Question 42

Decreased efficacy of levonorgestrel 1.5 mg (Plan B) is seen above what BMI?

Answer 42

25

Question 43

Levonorgestrel 1.5 mg (Plan B) stops working entirely in women over what BMI?

Answer 43

30

Question 44

What is ulipristal acetate (Ella) used for for?

Answer 44

Emergency contraception

Question 45

What is the onset of action of U-500?

Answer 45

30 - 45 minutes

Question 46

Metformin is contra-indicated equal to or above creatinine ______ in males.

Answer 46

1.5 mg/dL

Question 47

Metformin is contra-indicated with creatinine equal to and above ______ in females.

Answer 47

1.4 mg/dL

Question 48

Metformin is contraindicated in GFR less than ______.

Answer 48

45 mL/min/1.73m2

Question 49

Does cardiovascular risk correlate more with LDL cholesterol or LDL particle number?

Answer 49

LDL particle number

Question 50

Does metformin control blood glucose better in Black patients or White patients?

Answer 50

Black patients.

Question 51

Should the steroids be given before or after radioactive iodine ablation in patients with Graves Ophthalmopathy?

Answer 51

After.

Question 52

Which is the most common site of bone metastases due to thyroid cancer?

Answer 52

Spine

Question 53

Which is the dominant enzyme driving conversion from T4 to T3?

Answer 53

Deiodinase type 1

Question 54

What happens to deiodinase type 1 during fasting?

Answer 54

It is suppressed.

Question 55

What happens to T3 levels during fasting?

Answer 55

They decrease.

Question 56

What happens to the activity of deiodinase type 3 during fasting?

Answer 56

It is increased.

Question 57

Have randomized controlled trials shown benefit on patient outcomes of treating 'euthyroid sick syndrome' or 'non-thyroidal illness in the ICU' with therapeutic doses of T3 or T4?

Answer 57

No

Question 58

What happens to the plasma T3 levels in times of acute stress (acute illness, surgery, severe physical stress)?

Answer 58

T3 levels acutely fall.

Question 59

TSH has a normal nocturnal surge. True or false?

Answer 59

True

Question 60

What happens to the normal nocturnal TSH surge in acute illness?

Answer 60

It is absent.

Question 61

Vandetanib can prolong QT interval. True or false?

Answer 61

True

Question 62

High serum TSH levels are associated with retinal arteriolar narrowing. True or false?

Answer 62

True.