ENDO 2014

Question 0

When was the first patient treated with insulin?

Answer 0

1922

Boy named Thompson

Question 1

When was insulin discovered?

Answer 1

1921

Question 2

What is glypican-4?

Answer 2

Insulin receptor modulator.

Present mostly in insulin sensitive tissue

Question 3

How many grams of islet cells do we have in the human body?

Answer 3

Less then one gram.

Question 4

The definition of metabolic syndrome should be redefined in Asians because they get diabetes at lower BMI.
True or False!

Answer 4

True

Question 5

Low height is an independent predictor of gestational diabetes in Asians (Chinese).
True or false?

Answer 5

True

Question 6

Is there an association between air pollution and diabetes?

Answer 6

Yes. There is increased incidence of diabetes.

Question 7

Asian populations have been found to respond better to DDP-4 inhibitors as monotherapy and in combination therapies.
True or false.

Answer 7

True.

Meta analysis done in Kornea

Question 8

What is a universal marker for neuroendocrine tumors?

Answer 8

Chromogranin

Question 9

What proportion of patients with congenital precocious puberty (CPP) are found to have familial CPP?

Answer 9

25%

Question 10

What disease does Pasireotide treat?

Answer 10

Cushing’s disease.

Question 11

What should you do if you suspect partial di-iodinase deficiency?

Answer 11

Endo 2014 - increase the dose of T4

Sasan - add a little bit of T3

Question 12

The average height of patients with hemochromatosis are taller than general population?
True or false?

Answer 12

True

Question 13

Is hypophosphatasia acquired or inherited?

Answer 13

It is an inherited metabolic disorder

Question 14

Which is more effective at raising 25-OH vitamin D levels: D2 (ergocalciferol) or D3 (cholecalciferol)?

Answer 14

D3 (cholecalciferol).

Question 15

Low kisspeptin levels may predict miscarriage.

True or false?

Answer 15

True

Question 16

Does testosterone improve fertility?

Answer 16

No

Question 17

How much does testosterone level drop in men who lose a spouse?

Answer 17

By more than 10 years of ageing.

Question 18

What is abaloparatide?

Answer 18

PTHrP1-34 analog to treat osteoporosis

Question 19

What’s the failure rate of radioactive iodine in Grave’s disease?

Answer 19

About 10%

Question 20

Does radioactive iodine increase the risk of cancer?

Answer 20

Not really.

Risk equivalent of three chest x-rays

Question 21

When can you check a thyroid radioactive uptake scan in a patient who’s been on amiodarone?

Answer 21

When the patient has been off amiodarone for a year.

Question 22

What kind of ultrasound do you do thyroid disease?

Answer 22

Color flow Doppler

Question 23

What do you see on ultrasound in hyperthyroidism?

Answer 23

Increased vascular blood flow

Question 24

How soon after radioactive iodine therapy can patient become pregnant safely?

Answer 24

6 months

Question 25

How do you rule out familial hypocalciuric hypercalcemia?

Answer 25

Calculating fractional excretion of urine calcium - it should be less than < 0.01 (1%)

Question 26

Are parathyroid adenomas usually hyperechoic or hypoechoic?

Answer 26

Hypoechoic.

Question 27

What the are the two absolute contraindications for FNA biopsy of parathyroid adenoma?

Answer 27

• Familial jaw tumor hyperparathyroidism syndrome.

- Parathyroid carcinoma.

Question 28

Which route of administration of bromocriptine reduces the gastrointestinal side effects of the drug?

Answer 28

Intra-vaginal.

Question 29

Which is the longest acting dopamine agonist?

Answer 29

Cabergoline

Question 30

If a patient has subclinical hypothyroidism in pregnancy - should they be treated with levothyroxine?

Answer 30

Yes

Question 31

How should the dose of levothyroxine be changed after a hypothyroid pregnant patient delivers?

Answer 31

Decrease levothyroxine to pre-pregnancy level.

Question 32

Should the renin be suppressed or elevated when doing AVS for lateralisation of aldosterone source?

Answer 32

Suppressed