Fellowship - November 2014 Flashcards
Does metreleptin help with weight gain (when treating lipodystrophy)?
No - it does not help weight gain.
Why is mifepristone only FDA approved in diabetic or glucose intolerant patients?
Because glucose is the only reliable way of monitoring therapy.
What is the size of macroprolactin?
150 kDa
What is the size of Big prolactin?
50 kDa
What is the size of monomeric prolactin?
23 kDa
Is the biological activity of macroprolactin lower or higher than prolactin?
Lower
Does macroprolactinemia cause symptoms?
No
If a patient has galactorrhea or oligomenorrhea and has macroprolactinemia… Is the macroprolactinemia the cause?
No.
No data show the symptoms are related.
What symptom is low prolactin levels associated with?
Low libido
What does leptin do to appetite?
Suppresses it.
Does mifepristone cause hypo- or hyperkalemia?
Hypokalemia
On average how much glucose is filtered by the kidneys per day?
180 grams
Survival of patients with BRAF mutation is lower than those without.
True or false?
True
Can radioactive iodine treatment for Grave’s disease cause thyroiditis?
Yes
How is radioactive iodine induced thyroiditis treated?
NSAIDS
Baxerotene can cause low HDL that recovers when patient stops the medication.
True or false?
True
Do the pituitary and stalk have a blood brain barrier?
No
RANKL is on lymphocytes.
True or false?
True
What is the biggest trial with denosumab?
FREEDOM trial.
Which adrenal vein is harder to cannulate?
Right adrenal vein
If the Afirma is positive then what’s the chance of malignancy?
Approximately 40%
Vandetanib is approved for symptomatic or progressive medullary thyroid cancer in patients with unresectable locally advanced or metastatic disease.
True or false?
True
