Painkillers

Question 1

morphine
fentanyl
tramadol
oxycodone
opium
pethidine
codeine
heroin

Answer 1

Opioid/narcotic analgesic
painkiller
for pain

binds to opiate receptors to prevent release of substance P , stimulates analgesic effect.
= respiratory depression , vasodilation ,

Question 2

naloxone

Answer 2

antidote
- opioide overdose

binds to opiate receptors blocking bind of opioid analgesics.
= flushing , irritability , chills, sob

Question 3

aspirin

Answer 3

non-opioid analgesic , painkiller, NSAID, antiinflammatory , antipyretic
- pain, fever, swelling, cardiac issues

inhibits enzymes involved in prostaglandin synthesis. specifically blocks production of thromboxane at low dose
= gi bleed, peptic ulceration , vomiting. retention of water and sodium

Question 4

ibuprofen

Answer 4

non-opioid analgesic, painkiller, (NSAID), anti-inflammatory, antipyretic
- pain, swelling and fever

Inhibits enzymes involved in prostaglandin synthesis
= gi bleed, peptic ulceration , water/sod retention

Question 5

paracetamol

Answer 5

non-opioid analgesic , painkiller, antipyretic
- pain , fever

prevents production of certain prostaglandins in CNS and hypothalamus
= liver impairment, nausea, constipation

Question 6

celecoxib

Answer 6

Non-opioid analgesic, painkiller, anti-inflammatory, NSAID, antipyretic
- pain (esp- musculoskeletal pain).

selective reversible COX-2 inhibitor , inhibits prostaglandin production
= high bp , liver impairment, diarrhoea