Pain III Flashcards
What are the 2 componenents of pain
sensory-discriminative and emotional
How is prefrontal cortex involved in pain
cognitive aspects of pain percieved here
what role does anterior cingulate cortex have in pain
paying attention to pain
what roles does amygdala have in pain
fear, assign negative contex tto pain
how is hippocampus associated with pain
memory o fpain
insula
relay station to the limbic system and to the hypothalamus
when is anterior cingulate cortex active
perception of pain
imagining pain
observation of pain in others
when does gating mechanism close
in response to normal stimulation of fast conductivity large nerve fibers (a-beta)
when does gating mechanism open
slow conduction pain fibers (A delta and C fibers)
C fiber affect on inhibitory interneurons
inhibit inhibitory interneurons
activate secondary afferents
A bea affect on inhibiotry interneurons
activate inhibitory interneurons
What happens when C fibers inhibit inhibitory interneurons
activation of secondary afferents and transmissino of pain signal
what happens when A beta fibers acitivate inhibitory internerous
inhibition of secondary afferent and transmission of pain signaal
compeition between A beta and C fibers work to do what
decrease initial pain response
Sites of action for pain
periaquductal gray
rostral ventral medulla
locus-coerulues
how is pain moducated in periaquductral gray
activate enkephalin-releasing neurons that project to raphe nuclei in brainstem
what is analgesia in ventralateral PAG blocked by
naloxone
response to pain modulation in ventrolateral PAG
analgesia
decrease bp and HR
vasodilation of skeletal muscle and viscera
immobility
hwo does ventrolateral pain modulcation affect ANS
sympathetic inhibition
response to pain modulation in dorsal PG
decrease bp increase hr vasocontristion of skin and versia increase muscle tone aversive behavior
how does dorsal pain modulation affect ANS
sympathetic excitation
what are common pain types
chronic
referred
projected
neuropathic
reflective (referred) pain
percieved at location other than site of painful stimulus
convergence
somatic and viscersal pain fibers on secondary afferents in dorsal horn
projeced pain provides evidence to support wah tthroy
labeled line theory of sensory processing
what does phantom pain occur due to
neuroplasticity and reorganization
caudalagia
continuous burning pain long after seemingly trivial injuries
how do you treat reflex sympathetic dystrophy
sympathetic or sympathetic nerve block