Pain I Flashcards
nociception
sensory response to noxious stimulus
unconscious
pain
perception of nociceptive (noxious) sensory information - sensory and emotional
sensory-discrimination
perceptor of exteroceptive and enteroceptive noxious info and localization of site of stimulus
extercoeptive
information coming from outside
enteroceptive
information coming from within the body
motivation-affective
emotion and sympathetic responses and associated behaviors
what parts of the brain are associated with motivation-afferctive
frontal cortex, limbic system, brainstem area
type of sensation associated with acute (fast) pain
sharp, prickling, cutting
noceceptive pain
normal pain, transient localized, no tissue damage. warning/protective function
inflammatory pain
acute and chronic
tissue damage
hypersensitivity
protective, promotes heading
dysfunctional pain
no lesion found, disproportional to tissue damage (IBS)
neuropathic pain
damage to nervous system
pathologic, maladaptive
disproportionate to intensity of nociceptor activation
what is nociceptive pain caused by
activity in neural pathways in response to potentially tissue damgeing stimuli
mixed pain
nociceptive and neuropathic components
superifical somatic
close to surface
easy to localize
somatic deep
more difficult to localize
visceral pain
mediated by C fibers primarily
poorly localized
often radiates
free nerve endings in body
spinal ganglia
free nerve endings in face
trigeminal ganglia
why is high threshold important
because you don’t want to feel every sensation as pain
what are different pain stimuli
mechanical
thermal
chemical
inflammatory soup
release of ATP, bradykinin, serotonin
what happens after you have a tissue injury
release to inflammatory soup
what do inflammatory soup do
activate free nerve endings of noiceptors
what do nociceptors release
substance P
what does substance P do
vasodilation, more leaky blood vessels
edema and inflammation
stimulate mast cells to release histamin and NGF
silent nociceptors
do not respond to nociception initially, only signal in response to molecules secreted by other activated nociceptors
function of silent nociceptors
expand receptive field for pain stimulus
axon reflex
stimulation of sympathetic nervous system
