Oxygen Transportation

Question 1

Majority of oxygen due to low solubility is transported in what

Answer 1

Haemoglobin

Question 2

Haemoglobin is composed of what

Answer 2

4 protein chains, two alpha global and two beta units. Each unit contains a heme molecule

Question 3

Here is composed of what

Answer 3

Several carbon atoms that are linked to a central iron via nitrogen

Question 4

Iron component of heme is able to bind to oxygen how

Answer 4

Reversibly

Question 5

The higher the partial pressure of oxygen, the what? In terms of Haemoglobin

Answer 5

The higher the chance of oxygen being bound to Haemoglobin

Question 6

What is the Haemoglobin oxygen combination called and how is it written

Answer 6

Oxyhemoglobin, HbO2

Question 7

Haemoglobin that has released its oxygen is called

Answer 7

De oxyhemoglobin HHb

Question 8

Arrangement of atoms in heme molecule produces what colours when oxygen is bound and when oxygen is absent

Answer 8

Oxygen is bound - bright red

Oxygen absent - bluish red

Question 9

What is allosteric binding

Answer 9

When in the presence of high partial pressure of oxygen, binding of one Haemoglobin molecule to one heme group enhances the binding to the second heme group and so on

Question 10

Rate at which Haemoglobin binds/releases oxygen to regulated by what factors (5)

Answer 10

Po2, temperature, blood pH, Pco2, concentration of organic chemicals

Question 11

How does po2 effect binding in Haemoglobin

Answer 11

Increase in partial pressure of oxygen increase binding

Question 12

How does temperature effect binding in Haemoglobin

Answer 12

Increasing temp causes oxygen UNloading

Question 13

How does pH effect binding in Haemoglobin

Answer 13

If blood becomes too acidic (low pH, high H+ concentration) then HbO2 bonding is weaker and oxygen UNloading is higher

Question 14

What is Bohr effect

Answer 14

More H+ causes O2 to dissociate from HbO2

Question 15

How does pco2 effect binding in Haemoglobin

Answer 15

Increasing pco2 weakens the HbO2 bond as CO2 combines with H2O to produce bicarbonate and H+

Question 16

How does conc of organic chemicals effect binding in Haemoglobin

Answer 16

BPG a chemical produced by red blood cells, high level causes oxygen unloading

Question 17

From tissue to the blood plasma, what is released and picked up

Answer 17

Oxygen is released by the blood cells and CO2 is picked up from tissues

Question 18

From lungs and blood plasma, what is picked up and what is released

Answer 18

Oxygen in lungs is picked up by the blood cells. CO2 in blood cells is picked up by the lungs, released into the lungs.

Question 19

Oxygen in alveolus diffuses across resp membrane and combines with what in red blood cell and produces what. This then causes what reaction to occur in the red blood cell.

Answer 19

Oxygen combines with HHb in RBC and produces HbO2 and H+.

H+ then combines with HCO3 to make CO2 and H2O. CO2 released into alveolus

Question 20

When oxygen rich blood reaches oxygen poor blood, what things promote the RELEASE of oxygen from Haemoglobin into surrounding tissues where it is required

Answer 20

Conc gradient and temperature

Question 21

Why is only a small amount of oxygen transported in the plasma

Answer 21

Oxygen isn’t as soluble as carbon dioxide