OSA - 207 Flashcards

1
Q

What are the symptoms of OSA?

A

Loud snoring (95%)
Day time sleepiness
Un-refreshed sleep

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2
Q

What score can you use to grade/rank the likelihood of OSA?

A

Epworth sleepiness score

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3
Q

What is the definition of OSA?

A

Stopping or slowing breathing during sleep due to obstruction/narrowing in the upper airway -> pharyngeal incompetence

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4
Q

Is OSA more common in men or women?

A

Men.

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5
Q

In what category is OSA prevlance highest?

A

Type 2 diabetics

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6
Q

Name at least 5 risk factors for OSA

A
Obesity
Hypothyroidism
smoking
acromegaly
nasal problems
alcohol
sedatives
menopause
neuromuscular disease
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7
Q

Why is smoking a risk factor for OSA?

A

It causes pharyngeal oedema

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8
Q

What is type 1 respiratory failure?

A

Low O2 levels in the blood without high CO2 levels (hypercapnia).
Typically caused by VQ mismatch.

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9
Q

What is type 2 respiratory failure?

A

Low O2 levels and high CO2 levels (hypercapnia).

Caused by inadequate alveolar ventilation

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10
Q

COPD can cause what type of respiratory failure?

A

Type 2

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11
Q

High altitude can cause what type of respiratory failure?

A

Type 1

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12
Q

What happens to FEV1 and FVC in restrictive lung disease?

A

They are both reduced

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13
Q

What happens to FVC and FEV1 in obstructive lung disease?

A

FVC normal

FEV1 low

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14
Q

What type of Acid-Maltase Deficiency has the best prognosis?

A

Adult.

Juvenile has limited survival. Infantile (Pompe’s) has a poor prognosis, death is usually before 2 years

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15
Q

Why can people with acid maltase deficiency have difficulty swimming in pools?

A

Diaphragmatic involvement is common -> when lying supine the abdomen will fill the chest if the diaphragm is involved, this compresses the lungs.

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16
Q

What characterizes acid maltase deficiency?

A

Glycogen accumulation within lysosyme-derived vacuoles in nearly all cell types

17
Q

Where does the respiratory rhythm originate from?

A

The medulla oblongata

18
Q

What group of neurones fire during inspiration?

A

dorsal respiratory group

19
Q

What neurones fire during expiration?

A

ventral respiratory group

20
Q

Where is the respiratory rhythm ‘fine tuned’?

A

Pontine respiratory group (PRG)

21
Q

What is the main stimulus for breathing?

A

CO2