Orthopaedic pathology Flashcards
Type of bony met in prostate cancer
Sclerotic
Epiphysis
Giant cell tumour
Metaphysis
Osteosarcoma
Diaphysis
Ewing sarcoma
Multiple myeloma
Osteosarcoma demographic
Teenage boy
Sign in osteosarcoma
Codman’s triangle
Sunburst sign
Site of osteosarcoma met
Lung
Risk factors for osteosarcoma
Paget’s disease
Ewing sarcoma pathognomic
Onion ring appearance
Blue cells
11-22 chromosome translocation
Giant cell tumour XR appearance
Soap bubble
Osteochondroma demographic
Young teens, benign
Growth plate tumour
Chondroma vs chondrosarcoma
Chondroma - hands - benign
Chondrosarcoma - pelvis - malignant
Multiple myeloma signs
CRAB
Calcium - high
Renal failure
Anaemia
Bone lesions
XR signs multiple myeloma
Pepper pot appearance
Best imaging for osteomyelitis
MRI
Most common organism causing osteomyelitis
Staph aureus
Pott disease
M tuberculosis causing vertebral osteomyelitis and groin swelling
Most likely area in bone for osteomyelitis
Metaphysis
RA histology
Palisading epitheliod histiocyte/granuloma
Seronegative arthritis
HLA B27
PAIR
Psoriasis
Ank spond
IBD
Reactive arthritis
Gout
Monosodium urate needles
Negative biferingence
Pseudogout
Calcium pyrophosphate crystals
Positive birefringence
MOA denosumab
Blocks RANKL
Collagen anomaly in osteogenesis imperfecta
Type I collagen anomaly
Blue sclera due to lack of white collagen
Inheritance of osteogenesis imperfecta
Autosomal dominant
Gene mutation in achondroplasia
FGFR3 defect
Affects endochondral ossification
