Oral Path Exam 3 - Soft Tissue Masses Part 2 Flashcards
What lesion?
Benign neoplasm derived from Schwann cells
Granular cell tumor
What lesion?
Female predilection; rare in children
Granular cell tumor
What lesion?
Sessile submucosal nodule
Granular cell tumor
What lesion?
Pink, sometimes w/ yellow hue
Granular cell tumor
What lesion?
Most common site is dorsal tongue
Granular cell tumor
What lesions?
Diagnosed by biopsy
Granular cell tumor
Lipoma
Hemangioma
Kaposi sarcoma
Metastatic tumor
Peripheral odontogenic cysts/tumors
What lesions?
Tx = excisional biopsy
Granular cell tumor
Lipoma
Neurofibroma
Schwannoma
Peripheral odontogenic cysts/tumors
What lesion?
Benign tumor of fat
Lipoma
What lesion?
Uncommon in children
Lipoma
What lesion?
Soft, smooth-surfaced nodule
Lipoma
What lesion?
Usually yellow, sometimes can be pink
Lipoma
What lesion?
Most common sites are buccal mucosa and buccal vestibule
Lipoma
What lesion?
Benign vascular tumor
Hemangioma
What lesion?
Bright red to dull blue/purple nodule
Hemangioma
What lesion?
60% in head and neck
Hemangioma
What lesion?
More common in females
Hemangioma
What lesion?
Undergo rapid growth for 6-12 months, then involute
Hemangioma
What lesion?
90% resolve by age 9
Hemangioma
What lesions?
Tx = varies depending on subtype, location, and size
Hemangioma
Vascular malformation
What lesion?
Structural anomaly of blood vessels
Vascular malformation
What lesion?
Present at birth, but persist and may become more apparent throughout life
Vascular malformation
What lesion?
Can vary from pink/red macule to blue/purple mass
Vascular malformation
What lesion?
Presentation varies based on vasculature involved (capillary, venous, arteriovenous)
Vascular malformation
What lesion?
Port wine stains are common on the face (capillary malformations)
Vascular malformation
What lesion?
Diagnosed by aspiration (to confirm origin), imaging (angiogram), and biopsy
Vascular malformation
What is the name of a helpful clinical test that involves using a glass slide to compress a lesion you think may be vascular?
Diascopy
When doing a diascopy, vascular lesions tend to ___________ with pressure. Blood is displaced and lesion returns to normal color
blanch
What lesions?
Benign; nerve origin
Neurofibroma
Schwannoma
What lesion?
Most common oral site is tongue and buccal mucosa
(but can occur in many parts of the body)
Neurofibroma
What lesion?
Most common oral site is tongue
Schwannoma
The larger the salivary gland, the more likely it is to be __________.
The smaller the salivary gland, the more likely it is to be __________.
benign; malignant
Minor salivary glands have a 50% chance of being ___________
malignant
Which salivary gland makes up 70% of neoplasms, and 24% are malignant?
Parotid gland
Most salivary gland neoplasms are found here
Parotid gland
Which salivary gland makes up 10% of neoplasms, and 24% are malignant?
Submandibular gland
Which salivary gland makes up < 1% of neoplasms, and 83% are malignant?
Sublingual gland
Not many salivary gland neoplasms are found here, but when present, likely to be malignant
Sublingual gland
Which salivary gland makes up 19% of neoplasms, and 44% are malignant?
Minor salivary glands
What lesion?
Benign or malignant
Salivary gland tumor
What lesion?
Affects major or minor salivary glands
Salivary gland tumor
What are the 3 common sites for minor salivary gland neoplasms?
Hard palate
Soft palate
Upper lip
Name the 4 salivary gland tumors
Pleomorphic adenoma
Mucoepidermoid carcinoma
Polymorphous adenocarcinoma
Adenoid cystic carcinoma
Which salivary gland tumor?
Benign
Pleomorphic adenoma
Which salivary gland tumor?
Malignant
Mucoepidermoid carcinoma
Polymorphous adenocarcinoma
Adenoid cystic carcinoma
Which salivary gland tumor?
Most common salivary gland neoplasm
Pleomorphic adenoma
Which salivary gland tumor?
Can recur
Pleomorphic adenoma
Which salivary gland tumor?
Most common salivary gland malignancy
Mucoepidermoid carcinoma
Which salivary gland tumor?
Usually low-grade
Mucoepidermoid carcinoma
Polymorphous adenocarcinoma
Which salivary gland tumor?
Not found in major salivary glands
Polymorphous adenocarcinoma
Which salivary gland tumor?
More aggressive (perineural invasion)
Adenoid cystic carcinoma
What lesion?
Tx varies depending on benign vs malignant, location, histopathologic grade, and clinical stage
Salivary gland tumor
What lesion?
Tx = surgical excision, wide surgical excision, superficial parotidectomy, or total gland removal with or without neck dissection
Salivary gland tmor
One patient has a salivary gland neoplasm in their parotid gland and one patient has a salivary gland neoplasm in their sublingual gland.
Which is more likely to be malignant?
Sublingual gland neoplasm
What is the most common salivary gland
malignancy?
a. Pleomorphic adenoma
b. Mucoepidermoid carcinoma
c. Polymorphous adenocarcinoma
d. Adenoid cystic carcinoma
b. Mucoepidermoid carcinoma
What is the most common salivary gland neoplasm?
a. Pleomorphic adenoma
b. Mucoepidermoid carcinoma
c. Polymorphous adenocarcinoma
d. Adenoid cystic carcinoma
a. Pleomorphic adenoma
What is the most common site for a minor salivary gland neoplasm?
a. Gingiva
b. Hard palate
c. Ventral tongue
d. Floor of mouth
b. Hard palate
What lesion?
Group of malignancies characterized by overproduction of neoplastic WBCs
Leukemia
What lesion?
Originates in bone marrow, then spills over into circulating blood and tissues
Leukemia
What lesion?
Affects broad range of people
Leukemia
Lymphoma
Peripheral odontogenic cysts/tumors
What lesion?
Symptoms include fatigue, dyspnea, splenomegaly, hepatomegaly, lymphadenopathy, easy bruising/bleeding, fever
Leukemia
What lesion?
Diffuse, boggy, non-tender swelling of gingiva, with or without ulceration, asymptomatic
Leukemia
Acute or chronic leukemia?
More common in children and young adults
Acute
Acute or chronic leukemia?
Proliferation of immature WBCs
Acute
Acute or chronic leukemia?
More aggressive clinical course
Acute
Acute or chronic leukemia?
Occurs most frequently in middle-aged adults
Chronic
Acute or chronic leukemia?
Proliferation of mature WBCs
Chronic
Acute or chronic leukemia?
Slowly progressive clinical course
Chronic
What is the histogenesis for leukemia?
Lymphocytic/lymphoblastic
Myeloid
What does CLL stand for?
Chronic lymphocytic leukemia
What lesion?
Diagnosed by biopsy and bone marrow biopsy
Leukemia
What lesion?
Tx = chemo and bone marrow transplant
Leukemia
What lesion?
Group of malignant tumors of lymph nodes
Lymphoma
What lesion?
Originates in lymph nodes then can become more widely disseminated
Lymphoma
What lesion?
Enlarging, non-tender, discrete mass in lymph node region
Lymphoma
What lesion?
May have weight loss, fever, night sweats, and pruritus
Lymphoma
What lesion?
Oral non-tender, diffuse soft tissue swelling
(most commonly diffuse large B cell lymphoma)
Lymphoma
What lesion?
Most common oral sites are buccal vestibule, posterior hard palate, and gingiva
Lymphoma
What lesion?
Diagnosed by biopsy and imaging
Lymphoma
What lesion?
Tx = chemo
Lymphoma
What lesion?
Vascular malignancy
Kaposi sarcoma
What lesion?
Caused by infection with human herpesvirus 8 (HHV-8)
Kaposi sarcoma
What lesion?
Most commonly seen in pts with AIDS in the US
Kaposi sarcoma
What lesion?
Classic form seen in the Med, eastern Europe, and central equatorial Africa
Kaposi sarcoma
What lesion?
Endemic form seen in Africa
Kaposi sarcoma
What lesion?
Iatrogenic form seen in recipients of solid organ transplants
Kaposi sarcoma
What lesion?
90% in men
Kaposi sarcoma
What lesion?
Multiple blue/purple macules, plaques, and nodules on the face and oral mucosa
Kaposi sarcoma
What lesion?
Predilection for hard palate, gingiva, and tongue
Kaposi sarcoma
What lesion?
Tx = varies, usually involves management of AIDS and chemo
Kaposi sarcoma
What type of Kaposi sarcoma is most common in the United States?
a. Classic
b. Endemic
c. Iatrogenic
d. AIDS-related
d. AIDS-related
What lesion?
Spread of malignancy from another site
Metastatic tumors
What lesion?
Affects middle aged and older adults with cancer
Metastatic tumors
What are the common sites of origin for metastatic tumors for men?
Lung
Kidney
Melanoma
What are the common sites of origin for metastatic tumors for women?
Lung
Kidney
Breast
Genital
What lesion?
Nodular soft tissue mass resembling hyperplastic or reactive growth
Metastatic tumor
What lesion?
Most common oral site is the gingiva
Metastatic tumor
What lesion?
In 25% of pts, the primary malignancy is not diagnosed at time of oral metastasis presentation
Metastatic tumor
What lesion?
Tx = management of primary malignancy
Metastatic tumor
What lesion?
Poor prognosis
Metastatic tumor
What lesion has the following etiologies?
Goiter (most common)
Thyroid adenoma (benign)
Thyroid carcinoma (malignant)
Graves disease (more likely to be symptomatic)
Hashimoto’s thyroiditis (more likely to be symptomatic)
Thyroid gland enlargement
What lesion?
Mass in anterior midline of neck
Thyroid gland enlargement
What lesion?
Diffuse thyroid enlargement
Graves disease (hyperthyroidism)
What lesion?
Weight loss despite increased appetite
Graves disease (hyperthyroidism)
What lesion?
Tachycardia
Graves disease (hyperthyroidism)
What lesion?
Excessive perspiration
Graves disease (hyperthyroidism)
What lesion?
Warm, smooth skin
Graves disease (hyperthyroidism)
What lesion?
Tremors
Graves disease (hyperthyroidism)
What lesion?
Exophthalmos
Graves disease (hyperthyroidism)
What lesion?
Lethargy
Hashimoto’s thyroiditis (hypothyroidism)
What lesion?
Dry, course skin
Hashimoto’s thyroiditis (hypothyroidism)
What lesion?
Swelling of face and extremities
Hashimoto’s thyroiditis (hypothyroidism)
What lesion?
Huskiness of voice
Hashimoto’s thyroiditis (hypothyroidism)
What lesion?
Constipation
Hashimoto’s thyroiditis (hypothyroidism)
What lesion?
Bradycardia
Hashimoto’s thyroiditis (hypothyroidism)
What lesion?
Hypothermia
Hashimoto’s thyroiditis (hypothyroidism)
What lesion?
Diagnosed by fine needle aspiration, imaging, and bloodwork
Thyroid gland enlargement
What lesion?
Tx = varies based on etiology
Thyroid gland enlargement
What lesion?
Odontogenic neoplasms like peripheral ameloblastoma, peripheral calcifying epithelial odontogenic tumor, etc
Peripheral odontogenic cysts/tumors
What lesion?
Soft tissue mass on the gingiva
Peripheral odontogenic cysts/tumors
What is the most common oral soft tissue site for metastatic cancer?
Gingiva