Oral Path Exam 1 - Mixed Lesions and Radiolucent or Mixed Lesions Part 1 Flashcards
Mixed lesions always have a ____________ element and a _____________ element
radiopaque; radiolucent
The radiopaque component of the mixed lesion represents some sort of ___________
calcification
Where is the following calcification seen in a mixed lesion derived from?
Bone or cartilage
Bone
Where is the following calcification seen in a mixed lesion derived from?
Tooth-related material
Cementum, dentin, and/or enamel
Where is the following calcification seen in a mixed lesion derived from?
Dystrophic calcification
Pathologic
(if the tissue is dead, degenerative, or scarred)
What type of lesion?
Rare neoplasm that arises from the PDL
Cementoblastoma
What type of lesion?
Affects young adults
Found in the posterior mandible, especially the 1st permanent molar
Cementoblastoma
What type of lesion?
Symptoms = pain + swelling
Cementoblastoma
What type of lesion?
Looks like an opaque mass fused to root(s) and has a thin radiolucent rim around the mass in mature lesions
Cementoblastoma
What type of lesion?
Tx = conservative excision w/ either tooth root amputation and endo, or just ext
Cementoblastoma
Does cementoblastoma have a low or high recurrence?
Low recurrence
What type of lesion?
Histologically: cellular cementum with plump cementoblasts
Cementoblastoma
What type of lesion?
Histologically: often a periphery of radiating columns of calcified material
Cementoblastoma
What type of lesion may be mistaken for osteosarcoma?
Cementoblastoma
What is the most common odontogenic tumor?
Odontoma
What type of lesion?
Detected before 20 yrs, frequently associated with an unerupted tooth
Odontoma
What type of lesion?
Typically asymptomatic
Odontoma
What are the 2 types of odontomas?
Compound
Complex
What type of odontoma?
Found in anterior jaw
Compound odontoma
What type of odontoma?
May be associated with unerupted tooth
Compound odontoma
What type of odontoma?
Resembles small teeth (toothlets/denticles)
Compound odontoma
What type of odontoma?
Found in posterior jaw
Complex odontoma
What type of odontoma?
Dense radiopaque mass surrounded by radiolucent rim, usually pericoronal to impacted tooth
Complex odontoma
What type of odontoma?
Has odontogenic tissues, but does NOT form small tooth-appearing structures
Complex odontoma
What type of lesion?
Tx = enucleation, no recurrence
Odontoma
Benign or malignant/infectious/inflammatory?
Odontogenic cyst w/ calcification
Benign
Benign or malignant/infectious/inflammatory?
Odontogenic tumor w/ calcification
Benign
Benign or malignant/infectious/inflammatory?
Paget disease of bone
Benign
Benign or malignant/infectious/inflammatory?
Fibro-osseous lesions like fibrous dysplasia, cemento-osseous dysplasia, central ossifying fibroma
Benign
What type of lesion?
Also called the Gorlin cyst
Calcifying odontogenic cyst
What type of lesion?
Wide age range
Found in anterior jaw
Root resorption/divergence can be seen
Calcifying odontogenic cyst
What type of lesion?
Usually a unilocular radiolucency, but up to 50% can have calcifications (mixed appearance)
Calcifying odontogenic cyst
What type of lesion?
Tx = enucleation + curettage; unlikely recurrence
Calcifying odontogenic cyst
___________ odontogenic tumors can be radiolucent or mixed
Yellow
What are the 3 odontogenic tumor classifications?
Odontogenic epithelium
Odontogenic ectomesenchyme
Mixed (epithelium + ectomesenchyme)
What odontogenic tumor classification does the following fall under?
Ameloblastoma
Odontogenic epithelium
What odontogenic tumor classification does the following fall under?
Adenomatoid odontogenic tumor
Odontogenic epithelium
What odontogenic tumor classification does the following fall under?
Calcifying epithelial odontogenic tumor
Odontogenic epithelium
What odontogenic tumor classification does the following fall under?
Odontogenic fibroma
Odontogenic ectomesenchyme
What odontogenic tumor classification does the following fall under?
Odontogenic myxoma
Odontogenic ectomesenchyme
What odontogenic tumor classification does the following fall under?
Cementoblastoma
Odontogenic ectomesenchyme
What odontogenic tumor classification does the following fall under?
Ameloblastic fibroma
Mixed (epithelium + ectomesenchyme)
What odontogenic tumor classification does the following fall under?
Ameloblastic fibro-odontoma
Mixed (epithelium + ectomesenchyme)
What odontogenic tumor classification does the following fall under?
Compound or complex odontoma
Mixed (epithelium + ectomesenchyme)
What type of odontogenic tumor w/ calcification?
Looks identical to complex odontoma
Ameloblastic fibro-odontoma
All of the benign odontogenic cysts and tumors are asymptomatic or present with a slow growing swelling/expansion with either a unilocular or a multilocular presentation and +/- root divergence and resorption.
Unless secondarily infected, pain would only be expected with what?
Cementoblastoma
What are the 3 lesions that are clear cut features of a mixed appearance?
Compound odontoma
Complex odontoma
Ameloblastic fibro-odontoma
In lesions where you see calcification in the tooth-bearing portions of the jaws or in association with an unerupted/impacted tooth that can’t clearly be separated by presentation, how you can simplify the diff. dx?
Benign odontogenic cyst or tumor w/ calcification
What disease?
Also called osteitis deformans
Paget Disease of bone
What disease?
Increased/uncontrolled bone remodeling, resulting in thickened but distorted and weakened bones
Paget Disease of bone
What disease?
Unknown cause
Found in people older than 40
Anglo-Saxon ancestry
Paget Disease of bone
What disease?
May have bone pain, possible fractures, deafness, and blindness
Paget Disease of bone
What disease?
Most cases are polyostotic and affect the pelvis, femur, lumbar vertebrae, skull (hat doesn’t fit), and tibia
Paget Disease of bone
What disease?
When jaw is affected, causes symmetric enlargement (dentures don’t fit) and spaces develop between the teeth
Paget Disease of bone
What jaw is more often affected in Paget Disease of bone?
Maxillary
What disease?
Elevated total serum alkaline phosphatase (marker of osteoblastic activity)
Paget Disease of bone
What disease?
Chronic progression from vascular phase to late lesions that show patchy sclerosis (cotton-wool) appearance w/ thickened cortices
Paget Disease of bone
What disease?
Extensive hypercementosis of teeth
Paget Disease of bone
What disease?
Tx = NSAIDs for mild pain, bisphosphonates to slow bone turnover, and monitor pts for development of bone tumors
Paget Disease of bone
What type of bone tumor could a patient with Paget Disease of bone develop later?
Osteosarcoma
What disease?
Exts can be hard due to hypercementosis and ankylosis
Paget Disease of bone
What disease?
Place implants with caution!
Paget Disease of bone
What disease?
Surgical bleeding risk during vascular lytic phase
Paget Disease of bone
What disease?
Poor wound healing with risk for osteomyelitis during sclerotic phase
Paget Disease of bone
Non-specific term that describes a group of processes, with different pathogeneses, where normal bone is replaced by fibrous tissue with a newly formed mineralized product
Fibro-osseous lesions
Accurate diagnosis requires correlation of the clinical and radiographic features with the microscopic features because they can look very similar microscopically
Fibro-osseous lesions
What are the 3 fibro-osseous lesions of the jaws?
Fibrous dysplasia
Cemento-osseous dysplasia
Central ossifying fibroma
What type of fibro-osseous lesion?
Developmental, tumor like lesion due to a stimulatory G protein gene mutation (GNAS)
Fibrous dysplasia
What type of fibro-osseous lesion?
Presents in 20s or 30s
Slowly growing + painless swelling
Fibrous dysplasia
What type of fibro-osseous lesion?
Usually monostotic; jaws are affected
If polyostotic, can see cafe au lait pigmentation and endocrine issues
Fibrous dysplasia
What type of fibro-osseous lesion?
Maxillary lesions that involve adjacent facial bones can cause facial deformity
Fibrous dysplasia (craniofacial)
What type of fibro-osseous lesion?
Early lesions look radiolucent or mottled, followed by classic “ground glass” pattern with blending margins
Fibrous dysplasia
What type of fibro-osseous lesion?
Tx = surgical reduction if significant cosmetic or functional deformity; conservative management is advised!!
Fibrous dysplasia
What type of fibro-osseous lesion?
Benign neoplasm derived from bone, but often has cementum-like material in it as well
Central ossifying fibroma
What type of fibro-osseous lesion?
Most often found in the posterior mandible
Central ossifying fibroma
What type of fibro-osseous lesion?
Asymptomatic when small
Large lesions have painless swelling
Central ossifying fibroma
What type of fibro-osseous lesion?
Well-defined, unilocular, expansile, radiolucent or mixed
Central ossifying fibroma
What type of fibro-osseous lesion?
When mixed, it has a central radiopacity with a radiolucent periphery
Central ossifying fibroma
What type of fibro-osseous lesion?
May cause divergence or resorption of roots
Central ossifying fibroma
What type of fibro-osseous lesion?
During surgical exploration, lesion shells out as one potato-like mass
Central ossifying fibroma
What type of fibro-osseous lesion?
Made up of cellular fibrous CT w/ interspersed trabeculae or spherules of mineralized tissue that resembles bone and/or cementum
(need x-rays and history to diagnose!)
Central ossifying fibroma
What type of fibro-osseous lesion?
Tx = enucleation
Central ossifying fibroma
What type of fibro-osseous lesion?
Found in middle-aged females greater than 30, often in blacks
Cemento-osseous dysplasia
What type of fibro-osseous lesion?
Painless
No expansion
Found around tooth roots/apices
Cemento-osseous dysplasia
Are teeth vital or non-vital in cemento-osseous dysplasia?
Vital!
What type of fibro-osseous lesion?
Well-defined, irregular borders, unilocular radiolucency that develops a central radiopacity over time
Cemento-osseous dysplasia
What type of fibro-osseous lesion?
Tissue looks easily fragmented, gritty, red/brown early on; becomes more dense as it matures
Cemento-osseous dysplasia
What type of fibro-osseous lesion?
Tx = vitality testing to prevent doing RCT, take pano to check for multiple lesions, follow-up is all that is needed
Cemento-osseous dysplasia
What are the 3 variants of cemento-osseous dysplasia?
Focal
PA
Florid
Which variant of cemento-osseous dysplasia?
Solitary lesion in posterior mandible
Focal
Which variant of cemento-osseous dysplasia?
Mimics central ossifying fibroma, so it requires biopsy
Focal
Which variant of cemento-osseous dysplasia?
Multiple lesions in anterior jaw
PA
Which variant of cemento-osseous dysplasia?
Found in bilateral mandible (anterior + posterior) and can affect all 4 quadrants
Florid
Which variant of cemento-osseous dysplasia?
Dense radiopacities that CAN fuse to roots
Florid
Which variant of cemento-osseous dysplasia?
Bone exposure can cause secondary infection and sequestration
Florid