Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

CNS II > Opoids > Flashcards

Opoids Flashcards

1. List the three opioid receptor subtypes, the endogenous ligands for each receptor subtype, and the prototype exogenous opioid agonists that bind to each receptor subtype 2. List at least 8 important pharmacological effects produced by opioid agonists and name the receptor subtype that mediates each effect 3. Describe the differences in the pharmacology between full and partial opioid agonists 4. List the prototype opioid receptor antagonists, list which receptor subtype they bind to,

1
Q

three opioid receptor subtypes

A

Mu, Delta, Kappa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

role of Mu receptor

A

supraspinal analgesia, miosis, respiratory depression, euphoria, dependance

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

role of kappa receptor

A

spinal analgesia, sedation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

opioid receptor type

A

G protein

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

endogenous opioid that has affinity to mu

A

Beta

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

endogenous opioid that has affinity to delta

A

enkephalin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

endogenous opioid that has affinity to kappa

A

dynorphins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

path of pain sensation

A

peripheral stimulation creates APs –> APs travel up nerve to dorsal horn of SC –> up 2nd nerve to thalmus/brainstem –> 3rd nerve to cortex for pereption

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

where opiods work

A

spinal and supraspinal levels

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

opioid MOA in presynaptic terminal

A

decreases Ca++ influx in response to incoming APs - keeps neuron bouton from releasing NT

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

NT in pain circiut

A

substance P

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

opioid MOA in postsynaptic terminal

A

increases K+ conductance and thereby decreases the postsynaptic response to exitatory neurotransmission

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

analgesic effects of opioids

A

effective against dull pain
decreases response to pain
increases pain threshold

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

GI theraputic effects of opioids

A

increased tone and decreased motility

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

antitusive MOA of opioids

A

suppression of cough reflex in medullary center

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

adverse effects of opioids

A

respiratory depression, miosis, sedation, euphoria, emesis, urinary retention, bilary spasm, chest wall rigidity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

effects of opioids that tolerance occurs to

A

deppressent effects

18
Q

timimg of opioid withdrawal

A

begins 6 hrs after last dose, peaks at 48 hours, declines for 10 days

19
Q

sx of opioid withdrawal

A

sweating, nausea, vomiting, cramps, shivering, shakes, restlessness,

20
Q

most active forms of opioids

A

levo forms

21
Q

example mu-agonists (9)

A

morphine, heroin, codine, meperidine, fentanyl, congeners, methadone, propoxyphene, pentazocine, buprenorphine, tramadol

22
Q

reason heroin is more abused

A

higher potency, higher lipid soluability

23
Q

protoype mu agonist

A

morphine

24
Q

used as antitussive

A

codine

25
Q

mu agonist with anticholenergic effects

A

meperidine

26
Q

OD of this can lead to convulsions

A

meperidine

27
Q

opioids used as anesthetic adjuvants

A

fentanyl/ xxxx-entanil

28
Q

opioid that uses the dextro form

A

propoxyphene (darvocet)

29
Q

popular opioid for mild to moderate pain

A

propoxyphene

30
Q

partial mu agonist

A

pentazocine/buprenorphine

31
Q

alternative to methadone

A

buprenorphine

32
Q

use of tramadol

A

restless leg, fibromyalgia, acid reflux, premature ejacualtion

33
Q

MOA of tramadol

A

weak partial mu agonist, blocks NE reuptake, releases serotonin

34
Q

opioids that are metabolized to active compounds

A

morphine, meperidine, heroin, hydrocodone, oxycodone

35
Q

opioid antagonists

A

naloxone, naltrexone,

36
Q

short acting opioid antagonist

A

naloxone

37
Q

long acting opioid antagonist

A

naltrexone

38
Q

opioid antagonist used in maintaince therapy

A

naltrexone

39
Q

opioid antagonist used in emergency

A

naloxone

40
Q

anti-tussive that does NOT work on opiod receptors

A

dextromethorphan

41
Q

opioids used at anti-diarreha

A

loperamide and diphenoxylate

42
Q

widely abused prescription opioid

A

oxycodone

CNS II (25 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions