BS Stim abuse Flashcards
1. List the prototype methylxanthines, describe their mechanism of action and pharmacological effects, and list their major side effects. 2. List the prototype psychomotor stimulants, cocaine, and nicotine, describe their mechanism of action and pharmacological effects, and list their major side effects. 3. Describe the pattern and nature of abuse observed with psychomotor stimulants, cocaine and nicotine, the degree of tolerance and dependence, and the treatment of the abuse. 4. Describe the
meds for ADHD
methylphenidate, dextroamphetamine, mixed amphetamine salts
t 1/2 of cocaine
60-90 minutes
most intense/addictive route of amphetamine admin
IV
sx of acute amphetaminbe withdrawal
depression, feeling let down
MOA of cocaine
blocks catchecolamine reuptake
amphetamine MOA
taken up by pre-synaptic nerve endings and exchanged for catchecolamine NTs. Catchecolamine NTs released into synaptic cleft
medical uses for amphetamines
narcolepsy, ADHD,
drug of choice for blacks
Cocaine
drug of choice for whites
amphetamines
effects of very high doses of stimulants
suspicoisness, repetitive stereotyped behaviors, bruxism, sterotypy
treatment for stimulant OD
ABC, control the temp, dantroline, control seziures with diazepam
med for stim OD HBP
phentolamine
meds for stim OD agitation
diazepam, lorazepam
meds for stim OD psychosis
atypical antipsycotics (haldol)
sx of stimulant WD
sleepy, depressed, hungry, low concentration, craving
lenght of time of stim WD
sx lower over 3-4 days, can last over 2 months
treatment for stimulant induced psychosis
stop the stimulant
med to avoid in stimulant psychosis
benzo (disinhibition)
meds to try in stimulant WD
TCAs, dopamine agonists, disulfram, anticonvulsants,
