Intro to addiction

Question 1

most common drug (non EtOH) addiction

Answer 1

marijuana

Question 2

most common drug to start an addiction to recently

Answer 2

pain meds

Question 3

time in which drub addiction begins

Answer 3

adolecence

Question 4

most deadly drug addiction

Answer 4

nicotine

Question 5

drugs identified with alleles that may enhance addiction

Answer 5

nicotine and EtOH

Question 6

environmental factors associated with drug addiction

Answer 6

low SE class, poor parental support, drug availability

Question 7

substance abuse diagnostic criteria

Answer 7

one or more within 12 month period regarding recurrent substance abuse:

1) failure to fulfill major role in life
2) use in physically hazardous situations
3) recurrent legal problems
4) use despite persistant socal or interpersonal problems

Question 8

criteria of substance dependance

Answer 8

three of the following in the last 12 months

1) tolerance
2) withdrawal
3) increasing substance use
4) unsucessfull efforts to cut down or control use
5) great deal of time spent to get substance, use the substance, or recover from it’s effects
6) activies have been given up because of substance use
7) use continues despite knowledge that the substance is causing physical/psych problems

Question 9

dopamine produced in the (2)

Answer 9

substantia nigra and VTA

Question 10

dopamine targets

Answer 10

striatum, frontal cortex, hippocampus, nuc accumbens

Question 11

serotinin produced

Answer 11

raphe nucleus,

Question 12

serotinin target

Answer 12

nuc accumbens, striatum, cerebral cortex

Question 13

neurotransmitter mostly effected by substance abuse

Answer 13

dopamine

Question 14

receptors lowered in long term addiction

Answer 14

D2

Question 15

three pillars of drug abuse treatment

Answer 15

pharm, behavoral therapies, medical/social services

Question 16

relapse rates for drug abuse

Answer 16

40-60%

Question 17

highest predictor or sustained recovery

Answer 17

extended abstinence

Question 18

DSM criteria for nicotine withdrawal

Answer 18

dysphoric or depressed mood
insomnia
irritability
anxiety
difficulty concentrating
restlessness
bradycardia
increased appetite or weight gain

Question 19

time frame for nicotine withdrawal

Answer 19

begins in a few hours, increases over 3-4 days, grad decrease over 1-3 weeks

Question 20

drug therapy for nicotine addiction

Answer 20

replacement (patch, gum, lozenge, etc)
buproprion (wellbutrin)
varenicline (chantix)

Question 21

nicotine therapy drug that can cause psych sx, or suicde risk

Answer 21

varenicline

Question 22

MOA of buproprion

Answer 22

DA reuptake inhibtor/nic antagonist

Question 23

MOA of varennicline

Answer 23

partial nic receptor agonist

Question 24

3 principles of nic dependance

Answer 24

every pt who uses should be offered treatment
intensity of counseling directly related to effectiveness
adjuctive pharmacotherapy should be offered