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CNS II > Alcohol and seditive abuse > Flashcards

Alcohol and seditive abuse Flashcards

1. Describe the impact of alcohol and sedative/hypnotic use on individuals and society 2. Analyze a clinical scenario and choose the correct treatment for alcohol and sedative/hypnotic withdrawal 3. Analyze a clinical scenario and choose the correct treatment for alcohol dependence

1
Q

def of binge drinking

A

4 (women)/5 (men) drinks in one occasion

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2
Q

def of heavy drinking

A

1(women)/2( men) drinks a day on average

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3
Q

are most binge drinkers Et OH dependant

A

no

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4
Q

% of men/women who will meet criteria for EtOH dependance at some point in their lives

A

17 men/8% women

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5
Q

most common drug in ED misuse/abuse cases

A

benzos

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6
Q

gender most likely to have sedative abuse

A

women

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7
Q

usually fatal BAC

A

.5

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8
Q

sedatives with respiratory compromise by themselves

A

barbos

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9
Q

what must be given before glucose in an ER setting

A

thiamine

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10
Q

why must thiamine must be given before glucose in ER

A

prevent wernicke’s

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11
Q

pathology of wernicke-korsakoff’s

A

atrophy of mammillary bodies/thalmus

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12
Q

sx of wernickes

A

confusion, 3/4 CN lesion signs, ataxia, coma/death

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13
Q

sx of korsakoff’s

A

amnesia, confabulation, hallucinations

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14
Q

NT acted upon by EtOH

A

GABAA, glutamate

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15
Q

why do you “black out” when drunk

A

decrease in glu functioning on NMDA receptors

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16
Q

heritibility rate of EtOH dependance

A

50%

17
Q

predictors of EtOH withdrawal severity

A 
older age
lenght/severity of habit
prior withdrawal (kindling)
major med/surg problems
sedative/hypnotic use
18
Q

lab value to identify heavy drinkers

A

CDT

19
Q

time frame for DT’s

A

72-105hours

20
Q

when do AW seizures occur

A

24-48 hours

21
Q

DT sx

A

marked autonomic arousal
shakes, sweats, HTN, tachycardia
delerium

22
Q

drugs that can cause fatal withdrawal

A

EtOH, benzo, barbo

23
Q

treatment for Acute AW

A

benzo

24
Q

reasons for useing long t 1/2 benzo in AW

A

less seziures. smoother detox

25
Q

long t 1/2 benzos for AW

A

chlordiazepoxide, diazepam

26
Q

why would you use short t 1/2 benzo for AW

A

less oversedation, safer in elderly or with liver damage

27
Q

short t 1/2 benzo

A

lorazepam, oxazepam

28
Q

used to determine AW severity

A

CIWA

29
Q

the “make you sick” anti EtOH drug

A

disulfiram

30
Q

SE of disulfram

A

drowsy, fatigue, exacerbate psychosis/depression

31
Q

SE of naltrexone

A

liver damage, flu-like sx

32
Q

SE of acamprosate

A

dirrhea, bloating, rash

33
Q

MOA of disulfram

A

inhibits aldehyde dehygrongenase to allow unpleasant acetaldehyde accumulation

34
Q

acamprosate MOA

A

modulates activity of glu

35
Q

naltrexone MOA

A

modulates activity of endogenous opioids

CNS II (25 decks)

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