Opioid Analgesics Flashcards
How do opiates and opioids differ?
And opiate is derived from the poppy while an opioid is a general term that refers to things that bind opioid receptors
Where is the periaqueductal gray?
The midbrain
What is a Narcotic?
A legal term
Technically means sleep inducing
Opioids
What is the primary receptor for analgesia?
Mu (u)
What are some effects of Mu stimulation?
Analgesia
Respiratory depression
Constipation
Physical dependance
What is the kappa receptor?
Another opioid receptor
Analgesia
Sedation
Constipation
What receptor is responsible for modulating Mu activity?
Delta receptor
What triggers Mu receptors?
Endorphins
Endomorphins
What receptor do enkephalins trigger?
Delta receptors
What do dynorphins trigger?
Kappa receptors
What are opioid receptors coupled to?
G coupled receptors
What are two important outcomes of opioid receptor activation?
Inhibited calcium channels
Increased K channels efflux
What do opioids eventually do?
Inhibits presynaptic and post synaptic transmission
What is inhibited by opioids in the presynaptic neuron?
Calcium channels thereby blocking release of glutamate and substance p
What other pain meds act at calcium channels?
Gabapentin - blocks calcium channels