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Neuro Block 2 > NSAIDs > Flashcards

NSAIDs Flashcards

0
Q

What enzymes do NSAIDs target?

A

Lipoxygenase

Cyclooxygenase

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1
Q

What are some pros and cons of NSAIDs?

A

Few side effects

Low to moderate pain

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2
Q

What does cox 1 do?

A

Platelet aggregation
Vasodilation
Gastric cytoprotectin

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3
Q

What does cox 2 do?

A

Induced by acute inflammation

Inhibited by glucocorticoids

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4
Q

What is prostacyclin do?

A

Decreased platelet aggregation

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5
Q

What does thromboxane do?

A

Platelet aggregation

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6
Q

What does aspirin do?

A

Irreversibly inhibits both cox enzymes

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7
Q

What are the analgesic effects of NSAIDs mediated by?

A

Prostaglandins e and g

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8
Q

How are the antipyretic effects of NSAIDs mediated?

A

The hypothalamus

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9
Q

What is the main adverse effect of NSAIDs?

A

Gastric bleeding by inhibiting prostaglandins and prostacyclins which help build the mucosa

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10
Q

What effect do NSAIDs have on clotting time?

A

2x increase for 7days

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11
Q

How do NSAIDs stimulate respiratory distress and electrolyte disturbances?

A

Hyperventilation
Metabolic acidosis by uncoupling oxidative phosphorylation so lactic acid accumulates
Treat with bicarbonate

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12
Q

What are toxic effects of aspirin?

A

Tinnitus
Headache
Hearing loss

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13
Q

How do you treat aspirin overdose?

A

Vomit
Sodium bicarbonate
Transfusion
Dialysis

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14
Q

What causes aspirin hypersensitivity?

A

Nasal polyps are caused
Non immune mediated
Do to shunting of AA into the leukotriene pathway

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15
Q

How do you treat aspirin allergy?

A

Epinephrine avoid peptol bismol

16
Q

What is a severe reaction to aspirin?

A

Reye’s syndrome

17
Q

What can aspirin be used for?

A

Menstraul pain
Rheumatoid arthritis
Fever
Headache

18
Q

What is important about ibuprofen?

A

Not as much GI stuff

Reversible

19
Q

What is important about indomethacin?

A

Strongest cox inhibitor
Bad GI distress
Used as last choice
Used to treat patent ductus arterosis to make it close

20
Q

What is ketorolac?

A

IV
Can replace morphine
Combined with opioids

21
Q

What is celecoxib?

A

Selective cox 2 inhibitor

But increases heart attack and stoke

22
Q

What is acetaminophen?

A 
Not an NSAID 
Not many issues
Low therapeutic index
A metabolite is a free radical
Do not take with alcohol
23
Q

How do you treat acetaminophen overdose?

A

N-acetylcysteine

Only effective under 24 hrs

Neuro Block 2 (26 decks)

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