ONDANSETRON (Zofran®)

Question 1

Generic/Trade Name

ONDANSETRON

Answer 1

Zofran®

Question 2

Generic/Trade Name

Zofran®

Answer 2

ONDANSETRON

Question 3

ONDANSETRON (Zofran®)

Drug Classification:

Answer 3

Antiemetic

Question 4

ONDANSETRON (Zofran®)

Mechanism of Action:

Answer 4

5-HT3 (serotonin) R antagonist ⇒ based on the theory that 5-HT3 receptors are present at the vagal nerve terminals and binding of serotonin initiates vomiting reflex, Zofran would prevent this process

Question 5

ONDANSETRON (Zofran®)

Pharmacokinetics

Answer 5

Onset of Action = Est. 10-30 minutes

Peak Effects = Unknown

Duration of Effect = Unknown

Half-Life = 4 hours

Question 6

ONDANSETRON (Zofran®)

Indications/Field Use:

Answer 6

• Nausea
• Vomiting

Question 7

ONDANSETRON (Zofran®)

Contraindications:

Answer 7

Hypersensitivity

Question 8

ONDANSETRON (Zofran®)

Side Effects/Adverse Reactions:

Answer 8

• HA
• dizziness
• tachycardia
• chest pain
• constipation
• diarrhea
• dry mouth
• prolonged QT interval

Question 9

ONDANSETRON (Zofran®)

ADULT DOSE:

Answer 9

(ADULT): 4mg slow IVP (IO) over 2-5 min

Question 10

ONDANSETRON (Zofran®)

PEDI DOSE:

Answer 10

(PEDI): 0.1mg/kg slow IVP (IO) over 2-5 min

Question 11

ONDANSETRON (Zofran®)

Precautions:

Answer 11

Lower risk of sedation and dystonia

_{(I’m a tree, I’m a Monster)}

than other antiemetics

Question 12

ONDANSETRON (Zofran®)

Drug-Drug Interactions:

Answer 12

May affect clearance and half-life with inducers and inhibitors of Cytochrome P-450 enzymes (CYP3A4, CYP2D6, CYP1A2)