ATROPINE SULFATE

Question 1

ATROPINE SULFATE

ATROPINE SULFATE

Answer 1

ATROPINE SULFATE

Question 2

ATROPINE SULFATE

Drug Classification:

Answer 2

• Anticholinergic
• Parasympatholytic

Question 3

ATROPINE SULFATE

Mechanism of Action:

Answer 3

Acetylcholine receptor antagonist ⇒

• parasympathetic inhibition
• positive chronotropy
• no inotropic effect

Question 4

ATROPINE SULFATE

Pharmacokinetics

Answer 4

Onset of Action = Immediate

Peak Effects = 2-4 minutes

Duration of Effect = 4 hours

Half-Life = 2-3 hours

Question 5

ATROPINE SULFATE

Indications/Field Use:

Answer 5

• Symptomatic (AMS, pulmonary edema, hypotension, chest pain)
  bradycardia
• Premedication for RSI with bradycardia <50bpm
• Organophosphate poisoning

Question 6

ATROPINE SULFATE

Contraindications:

Answer 6

No longer recommended for PEA and asystole

Question 7

ATROPINE SULFATE

Side Effects/Adverse Reactions:

Answer 7

• Blurred vision
• dilated pupils
• dry mouth
• tachycardia
• drowsiness
• confusion

Question 8

ATROPINE SULFATE

ADULT DOSE:

Answer 8

Bradycardia (ADULT): 0.5mg q3-5min IV, IO up to 3mg

RSI (ADULT): 0.5-1mg IV, IO

Organophosphate (ADULT): 2-5mg

Question 9

ATROPINE SULFATE

PEDI DOSE:

Answer 9

Bradycardia (PEDI): 0.02mg/kg IV, IO; minimum single dose 0.1mg; max single dose 0.5mg

RSI (PEDI): 0.02mg/kg IV, IO

Organophosphate (PEDI): 0.02-0.05mg/kg IV, IO, q20-30min until S/S resolve

Question 10

ATROPINE SULFATE

Precautions:

Answer 10

• Do not give less than 0.5mg (ADULT) or 0.1mg (PEDI) – causes paradoxical effect
• May cause paradoxical slowing or may be ineffective if used for 2° Type II / 3° Heart Block
• Increases myocardial oxygen demand

Question 11

ATROPINE SULFATE

Drug-Drug Interactions:

Answer 11

Few EMS