METOPROLOL (Lopressor®)

Question 1

Generic/Trade Name

METOPROLOL

Answer 1

Lopressor®

Question 2

Generic/Trade Name

Lopressor®

Answer 2

METOPROLOL

Question 3

METOPROLOL (Lopressor®)

Drug Classification:

Answer 3

β Blocker

Question 4

METOPROLOL (Lopressor®)

Mechanism of Action:

Answer 4

β1 R-antagonist ⇒ negative inotropy, chronotropy

Question 5

METOPROLOL (Lopressor®)

Pharmacokinetics

Answer 5

Onset of Action = Immediate

Peak Effects = 20 minutes

Duration of Effect = 13-19 hours (or 5-8hr?)

Half-Life = 3-4 hours

Question 6

METOPROLOL (Lopressor®)

Indications/Field Use:

Answer 6

• SVT refractory to adenosine
• A-fib, a-flutter, stable narrow complex tachycardia

Question 7

METOPROLOL (Lopressor®)

Contraindications:

Answer 7

• HR < 45 BPM, Systolic BP < 100mmHg
• CHF
• any heart block
• asthma
• shock
• bronchospasm

Question 8

METOPROLOL (Lopressor®)

Side Effects/Adverse Reactions:

Answer 8

• Bradycardia
• hypotension
• lethargy
• CHF
• dyspnea
• wheezing
• weakness

Question 9

METOPROLOL (Lopressor®)

ADULT DOSE:

Answer 9

(ADULT): 5mg slow IVP (IO) q 2-5min, max dose 15mg

Question 10

METOPROLOL (Lopressor®)

PEDI DOSE:

Answer 10

Not for Pediatric Patients

Question 11

METOPROLOL (Lopressor®)

Precautions:

Answer 11

• Watch for onset CHF
• shock
• bronchospasm
• bradycardia
• heart block

Question 12

METOPROLOL (Lopressor®)

Drug-Drug Interactions:

Answer 12

• Caution Pt.’s taking antihypertensives
• do not give to Pt. who has received IV Verapamil (or other Ca2+ channel blocker?)