Acetominophen(tylenol) Flashcards
0
Q
Acetominophen(Tylenol)
Mechanism
A
COX inhibitor => elevated pain threshold, antipyretic by action on hypothalamic heat regulatory center
1
Q
Acetominophen(Tylenol)
Class
A
Antipyretic/analgesic
2
Q
Acetominophen(Tylenol)
Pharmacokinetics
A
Onset: 15-30 min
Peak: 30-120 min
Duration: 3-4 hrs
1/2 life: 1-3 hrs
3
Q
Acetominophen(Tylenol)
Indications
A
- fever
- mild- moderate pain
4
Q
Acetominophen(Tylenol)
Contraindications
A
- hypersensitivity
- pt with liver desease
5
Q
Acetominophen(Tylenol)
Side effects
A
- dizziness
- abdominal pain
- hypoglycemia
- n+v
6
Q
Acetominophen(Tylenol)
Dose
A
(Adult): 325-650 mg PO q 4-6 hrs prn, max dose 4 g a day
(Pedi): 15mg/kg PO q 4-6 hrs prn, max dose 4 g a day
7
Q
Acetominophen(Tylenol)
Precautions
A
- Metabolized by liver- overdose can be toxic
- doesn’t have anti-platelet aggregation effect
- doesn’t have peripheral anti-inflammatory effect
8
Q
Acetominophen(Tylenol)
Drug to drug
A
Chronic excessive use of alcohol increases risk of hepatotoxicity
