AMIODARONE HCL (Cordarone®)

Question 1

Generic/Trade Name

AMIODARONE HCL

Answer 1

Cordarone®

Question 2

Trade/Generic:

Cordarone®

Answer 2

AMIODARONE HCL

Question 3

AMIODARONE HCL (Cordarone®)

Drug Classification:

Answer 3

Antidysrhythmic agent

Question 4

AMIODARONE HCL (Cordarone®)

Mechanism of Action:

Answer 4

• Class III Antiarrhythmic/K+ channel blocker ⇒ Prolongs cardiac action
  potential duration and refractory period
• Demonstrates properties of Na+/Ca2+ channel blockers
• Noncompetitive inhibitor of α and β adrenergic receptors

Question 5

AMIODARONE HCL (Cordarone®)

Pharmacokinetics

Answer 5

Onset of Action = Immediate

Peak Effects = 30-45min

Duration of Effect = Varies

Half-Life = 40-55 days

Question 6

AMIODARONE HCL (Cordarone®)

Indications/Field Use:

Answer 6

• Cardiac Arrest (VF, Pulseless VT)
• Wide Complex Tachycardia

Question 7

AMIODARONE HCL (Cordarone®)

Contraindications:

Answer 7

• Cardiogenic shock
• severe sinus node dysfunction
• marked or symptomatic
  bradycardia
• 2º/3º Heart Block
• hypersensitivity

Question 8

AMIODARONE HCL (Cordarone®)

Side Effects/Adverse Reactions:

Answer 8

• Hypotension
• bradycardia
• dyspnea
• cough
• dizziness
• Prolonged PR, QRS, QT intervals
• increased ventricular beats

Question 9

AMIODARONE HCL (Cordarone®)

ADULT DOSE:

Answer 9

• VF/Pulseless VT (ADULT): 300mg IV, IO, repeat dose 150mg IV, IO in 3-5min PRN
• VT + Pulse (ADULT): 150mg IV, IO over 10 min
• Maintenance (ADULT): 1mg/min first six hours, then 0.5mg/min

Question 10

AMIODARONE HCL (Cordarone®)

PEDI DOSE:

Answer 10

• VF/Pulseless VT (PEDI): 5mg/kg IV, IO; max dose 300mg, max total dose 15mg/kg
• VT + Pulse (PEDI): 5mg/kg IV, IO over 20-60 min; max dose 300mg

Question 11

AMIODARONE HCL (Cordarone®)

Precautions:

Answer 11

Caution patients with heart failure

Question 12

AMIODARONE HCL (Cordarone®)

Drug-Drug Interactions:

Answer 12

Warfarin, digoxin, procainamide, quinidine, phenytoin