Ondansetron (Zofran)

Question 1

Ondansetron Class?

Answer 1

Antiemetic

Question 2

Ondansetron Action?

Answer 2

First selective serotonin blocking agent to be marketed. Blocks the serotonin 5-HT3 receptors that are found centrally in the chemoreceptor trigger zone and peripherally at the vagal nerve terminals in the intestines which in turn minimizes nausea and vomiting.

Question 3

Ondansetron Indications?

Answer 3

Nausea and vomiting

Question 4

Ondansetron Contraindications?

Answer 4

Hypersensitivity, GI obstruction, and use caution with liver disease pt’s.

Question 5

Ondansetron Onset/Duration?

Answer 5

Onset: 15-30 min
Duration: 3-6 hr

Question 6

Ondansetron Dose/Route?

Answer 6

Adult: 4 mg IV/IO/IM

Peds: 0.15 mg/kg IV/IO/IM

Question 7

Ondansetron Side Effects?

Answer 7

ECG irregularities (rare), dizziness, headache, hiccups, pruritus, chills, drowsiness