Aspirin (Salicylate)

Question 1

Aspirin Class?

Answer 1

Analgesic, NSAID, antipyretic, and antiplatelet

Question 2

Aspirin Action?

Answer 2

Inhibits prostaglandins involved in the production of inflammation, pain and fever. Dilates peripheral vessels and also inhibits platelet aggregation by blocking the formation of thromboxane A2.

Question 3

Aspirin Indications?

Answer 3

ACS such as myocardial infarction, ischemic chest pain or angina, mild or moderate pain or fever

Question 4

Aspirin Contraindications?

Answer 4

GI bleeding, hemorrhagic stroke, active gastric ulcers, bleeding disorders, asthma, hypersensitivity to salicylates, children

Question 5

Aspirin Onset/Duration?

Answer 5

Onset : 15 - 30 mins

Duration : 4 - 6 hours

Question 6

Aspirin Dose/Route?

Answer 6

Adult : Mild pain/Fever - 325-650 mg PO every 4 hours. ACS - 2 to 4 baby aspirin 162-324mg PO

Peds : Not indicated

Question 7

Aspirin Side Effects?

Answer 7

Stomach irritation, GI bleeding, nausea and vomiting

Question 8

Aspirin Note*

Answer 8

Children under 12 should not be given. Aspirin as they may develop Reye’s syndrome