Ipratropium (Atrovent)

Question 1

Ipratropium Class?

Answer 1

Anticholinergic, bronchodilator

Question 2

Ipratropium Action?

Answer 2

Ipratropium blocks interaction of acetylcholine at receptor sites on bronchial smooth
muscle resulting in bronchodilation, reduced mucus production, and decreased levels of cyclic
guanosine monophosphate.

Question 3

Ipratropium Indications?

Answer 3

Persistent bronchospasms, asthma, COPD exacerbation

Question 4

Ipratropium Contraindications?

Answer 4

Hypersensitivity to ipratropium, atropine, soybean protein, or peanuts

Question 5

Ipratropium Onset/Duration?

Answer 5

Onset: < 15 min
Duration: 2-4 hrs

Question 6

Ipratropium Dose/Route?

Answer 6

Adult: 0.5 mg diluted in 2.5 ml NS via nebulizer. May repeat dose twice per most
protocols

Peds: Not typically given prehospital. 250-500 mcg diluted in 2.5 ml saline via nebulizer
every 20 mins up to 3 doses

Question 7

Ipratropium Side Effects?

Answer 7

Mydriaisis, tachycardia, blurred vision, nausea/vomiting, headache, anxiety,
blurred vision.