Lorazapam (Ativan)

Question 1

Lorazapam Class?

Answer 1

Benzodiazepine

Question 2

Lorazapam Action?

Answer 2

Increases the activity of the inhibitory neurotransmitter GABA, thereby producing a
sedative effect, relaxing skeletal muscles, and raising the seizure threshold.

Question 3

Lorazapam Indications?

Answer 3

Seizures, agitation, anxiety, alcohol withdrawal.

Question 4

Lorazapam Contraindications?

Answer 4

Hypersensitivity, hypotension, respiratory depression, CNS depression.

Question 5

Lorazapam Onset/Duration?

Answer 5

Onset: 2-10 min IV
Duration: 6-8 hrs

Question 6

Lorazapam Dose/Route?

Answer 6

Adult: 1-4 mg IM/IV, every 15-20 min up to 8 mg max total dose.

Peds: 0.1 mg/kg IV/IO/IM/PR/IN over 2 min, can be repeated once in 5-10 min up to 4
mg.

Question 7

Lorazapam Side Effects?

Answer 7

Respiratory depression, hypotension, tachycardia, bradycardia, CNS depression,
blurred vision.