Norepinephrine (Levophed)

Question 1

Norepinephrine Class?

Answer 1

Sympathomimetic, vasopressor

Question 2

Norepinephrine Action?

Answer 2

Alpha-1 and beta-1 agonist, causing vasoconstriction and increased myocardial contractility

Question 3

Norepinephrine Indications?

Answer 3

Cardiogenic shock, neurogenic shock, hemodynamically significant hypotension refractory to other sympathomimetics.

Question 4

Norepinephrine Contraindications?

Answer 4

Hypotension due to hypovolemia

Question 5

Norepinephrine Onset/Duration?

Answer 5

Onset: 1-3 min
Duration: 5-10 min

Question 6

Norepinephrine Dose/Route?

Answer 6

Adult: 2-20 mcg/min IV, titrated to effect

Peds: 0.05-0.1 mcg/kg/min IV, titrated to effect up to max of 2 mcg/kg/min

Question 7

Norepinephrine Side Effects?

Answer 7

Headache, dysrhythmias, tachycardia, reflex bradycardia, angina pectoris, hypertension

Question 8

Norepinephrine Notes*

Answer 8

Beta-adrenergic antagonists may blunt inotropic response. Can cause tissue necrosis if extravasation occurs.