Ibuprofen

Question 1

Ibuprofen Class?

Answer 1

Nonsteroidal Anti-Inflammatory (NSAID)

Question 2

Ibuprofen Action?

Answer 2

Slows prostaglandin synthesis by inhibiting COX-1 and COX-2 enzymes, thereby decreasing inflammation.

Question 3

Ibuprofen Indications?

Answer 3

Pain, fever, various inflammatory disorders.

Question 4

Ibuprofen Contraindications?

Answer 4

Hypersensitivity, bleeding disorders, renal failure or disease, active peptic ulcer disease, preterm infants with infection, congenital heart disease from patent ductus arteriosis.

Question 5

Ibuprofen Onset/Duration?

Answer 5

Onset: 30-60 min
Duration: 6-8 hrs

Question 6

Ibuprofen Dose/Route?

Answer 6

Adult: 400-800 mg PO, every 6-8 hrs

Peds: 10 mg/kg PO, up to 400 mg every 4-6 hrs

Question 7

Ibuprofen Side Effects?

Answer 7

Bleeding disorders, nausea, headache, rash, edema.

Question 8

Ibuprofen Note*

Answer 8

May antagonize effects of Angiotensin Converting Enzyme (ACE) inhibitors, beta blockers, angiotensin-receptor antagonist medications, salicylates, and certain classes of diuretic medications.