Methylprednisolone (Solu-Medrol)

Question 1

Methylprednisolone Class?

Answer 1

Corticosteroid, Glucocorticoid

Question 2

Methylprednisolone Action?

Answer 2

Synthetic steroid that suppresses acute and chronic inflammation. It also potentiates vascular smooth muscle relaxation by beta-adrenergic agonists and may alter airway hyperactivity.

Question 3

Methylprednisolone Indications?

Answer 3

Anaphylaxis, asthma unresponsive to bronchodilators, adrenal insufficiency

Question 4

Methylprednisolone Contraindications?

Answer 4

Caution in pt’s with GI bleeding, diabetes, severe infection

Question 5

Methylprednisolone Onset/Duration?

Answer 5

Onset: 1-2 hrs
Duration: 8-24 hours

Question 6

Methylprednisolone Dose/Route?

Answer 6

Adult: 125 mg IV

Peds: 1-2 mg/kg IV

Question 7

Methylprednisolone Side Effects?

Answer 7

hypertension, hypokalemia, headache, alkalosis, sodium and water retention

Question 8

Methylprednisolone Note*

Answer 8

Use in spinal injury and shock is controversial