Oncology/palliation Flashcards
What are the chemptherapy emergencies?
Neutropenic sepsis, chemotherapy hypersensitivity,
Tumour lysis syndrome
Define neutropenic sepsis
Chenotherapy induced bone marrow suppression -myelosuppression
Featuring: neutropenia, anaemia, thrombocytopenia
Patient got a fever following chemitherapy?
Needs urgent FBC/ antibiotics/ resuscitation
Treat as neutropenic sepsis - medical emergency
Do sepsis 6
Low threshold for critical care
What condition caused by liver mets and release of serotonin into systemic circulation causes flushing, diarrhoea bronchospasm and hypotension ?
Carcinoid syndrome
What syndrome predisposing to colon cancers consist of PTEN mutations and intestinal hamartomas?
Cowden disease
What syndrome is associated with Germaine mutations of DNA mismatch repair genes?
HNPCC (Lynch syndrome)
When are syringe drivers used?
When a patient is unable to take oral medication due to nausea, dysphagia, intestinal obstruction, weakness or coma
What drugs are commonly added to syringe drivers to manage bowel colic?
hyoscine butylbromide
What drugs are commonly added to syringe drivers to manage respiratory secretions?
hyoscine hydrobromide
What drugs are commonly added to syringe drivers to manage nausea and vomiting ?
Metoclopromide, cyclazine
What drugs are commonly added to syringe drivers to manage pain?
Diamorphine is the preferred opioid
What drugs are commonly added to syringe drivers to manage agitation/ restlessness ?
midazolam, haloperidol, levomepromazine
