Oncology💛

Question 1

Preferred treatment for tumour lysis syndrome?

Answer 1

IV rasburicase

Question 2

What does Rasburicase do for tumour lysis syndrome?

Answer 2

Reduces uric acid levels - preventing AKI

Question 3

What should you monitor after starting dexamethasone?

Answer 3

Blood glucose

Question 4

Rasburicase MOA

Answer 4

Converts uric acid to a more soluble compound (allantoin)

Question 5

Management of neutropenic sepsis

Answer 5

IV pip-taz

Question 6

Metabolic disturbances in tumour lysis syndrome

Answer 6

Hyperkalaemia
Hyperphosphataemia
Hyperuricaemia
Hypocalcaemia

Question 7

Prophylactic agent for tumour lysis?

Answer 7

Allopurinol

Question 8

1st line treatment for Neoplastic spinal cord compression?

Answer 8

Oral dexamethasone

Question 9

Imaging contraindicated in patients with pacemakers?

Answer 9

MRI

Question 10

Treatment for neutropenic sepsis if there’s a penicillin allergy?

Answer 10

IV meropenem

Question 11

Initial management of metastatic cord compression

Answer 11

High dose dexamethasone AND 16mg IV STAT

PPI alongside

Question 12

Acute management of SVCO

Answer 12

Elevate head
Oxygen

Question 13

Definitive treatment of SVCO

Answer 13

Vascular stenting

Question 14

Sepsis six

Answer 14

Give oxygen, IV antibiotics, and fluids

Take lactate, urine output, blood cultures

Question 15

Gene mutation causing hereditary retinoblastoma

Answer 15

RB1

Question 16

Gene affected in MEN2

Answer 16

RET

Question 17

What cancer often has signet ring cells?

Answer 17

Gastric adenocarcinoma

Question 18

‘Double duct’ sign is seen in what cancer?

Answer 18

Pancreatic

Question 19

Drug used for N&V associated with intracranial disease

Answer 19

Cyclizine

Question 20

Chemo drug causing peripheral neuropathy

Answer 20

Vinblastine - NHL

Question 21

First line treatment for breathlessness in EOL

Answer 21

Morphine

Question 22

What genes have mutation in HNPCC

Answer 22

MSH1/MSH2