Haematology🩸

Question 1

What does TAILS stand for?

Answer 1

Thalassaemia
Anaemia of chromic disease
Iron deficiency
Lead poisoning
Sideroblastic

Question 2

HbA2 results in B thalassaemia

Answer 2

High

Question 3

HbA2 results in alpha thalassaemia

Answer 3

Normal or low

Question 4

Key symptoms of anaphylactic blood transfusion reaction (3)

Answer 4

Resp distress
Wheezing
Skin - rash

Question 5

Initial management of cold AIHA

Answer 5

Avoid cold

Question 6

Initial management of warm AIHA

Answer 6

Prednisolone

Question 7

Factor reduced in haemophilia B

Answer 7

IX

Question 8

Management for severe haemophilia B

Answer 8

Prophylactic recombinant factor IX

Question 9

What is the Philadelphia chromosome

Answer 9

Translocations between 9 and 22

Question 10

Philadelphia chromosome is hallmark of what blood cancer

Answer 10

CML

Question 11

Diagnostic test for ALL

Answer 11

Bone marrow biopsy and aspiration

Question 12

“Dry tap” on bone marrow aspiration is usually due to what

Answer 12

Bone marrow fibrosis

Question 13

First line treatment for symptomatic myelofibrosis

Answer 13

Ruxolitinib

Question 14

Ruxolitinib MOA

Answer 14

JAK1/2 inhibitor

Question 15

Characteristic blood results of warm AIHA (5)

Answer 15

Haemolysis
Reticulocytosis
Elevated bilirubin
Raised LDH
Low haptoglobin

Question 16

What does Coomb’s test test for

Answer 16

Direct antiglobulin - IgG and/or C3d

Question 17

Initial CML treatment

Answer 17

Imatinib

Question 18

Imatinib MOA

Answer 18

tyrosine kinase inhibitor

Question 19

Presence of what genes confirms CML

Answer 19

BCR-ABL1 fusion
Philadelphia chromosome

Question 20

Lymphoma with alcohol induced pain

Answer 20

Hodgkin’s

Question 21

DIC is characterised by what feature

Answer 21

Simultaneous thrombosis and bleeding due to consumption of clotting factors and platelets

Question 22

Haemophilia blood test results - aPTT, PT, bleeding time

Answer 22

Prolonged aPTT
Normal PT
Normal bleeding time

Question 23

Intrinsic pathway dysfunction leads to prolonged what

Answer 23

Prolonged aPTT

Question 24

Management of TACO

Answer 24

Stop transfusion
Furosemide

Question 25

Symptoms of AML (4)

Answer 25

Fatigue Frequent infections Bruising Bleeding

Question 26

Polycythemia Vera can progress to what blood cancer

Answer 26

CML

Question 27

Clopidogrel MOA

Answer 27

Irreversible inhibitor of P2Y12 receptor on platelets, preventing ADP-induced activation of GPIIb/IIIa receptors complex

Question 28

Which haemophilia is more likely

Answer 28

A

Question 29

Smudge cells suggest what

Answer 29

CLL

Question 30

AML findings on blood film

Answer 30

Auer rods

Question 31

Howell-Jolly bodies suggest what

Answer 31

Splenic dysfunction or absence

Question 32

4 features of acute haemolytic transfusion reaction

Answer 32

Fever Hypotension Nausea Anxietu

Question 33

2 Symptoms which suggest haemolysis

Answer 33

Fatigue Mild jaundice

Question 34

Reed-Sternberg cells are present in which blood cancer

Answer 34

Hodgkin’s

Question 35

EBV is a risk factor for which blood cancer

Answer 35

Hodgkin’s

Question 36

First line anti platelet for PV

Answer 36

Low-dose aspirin

Question 37

What is Richter’s transformation

Answer 37

Usually CLL, progressing to more aggressive lymphoma, usually diffuse large B cell

Question 38

2 characteristic features of aplastic anaemia - bloods, and bone marrow

Answer 38

Pancytopenia Hypo cellular bone marrow

Question 39

Initial treatment for mild-moderate haemophilia A

Answer 39

Desmopressin DDAVP

Question 40

Sickle cell crisis initial management

Answer 40

IV morphine