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Clerkship Prep > Oncology > Flashcards

Oncology Flashcards

1
Q

Smooth muscle cancer

A

Leiomyosarcoma

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2
Q

Skeletal muscle cancer

A

Rhabdomyosarcoma

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3
Q

Vessel cancer

A

ANGII sarcoma

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4
Q

TNM staging

A

T - tumour size
N - how many nodes
M - has it spread

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5
Q

NX cancer staging

A

Regional nodes cannot be assessed

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6
Q

N0 cancer staging

A

No regional lymph node mets

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7
Q

N1 cancer staging

A

Regional lymph node metastasis

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8
Q

Sarcomas (CT malignancies) often metastasize to

A

The lungs

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9
Q

LDH increase is suspicious for which cancer

A

Lymphoma

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10
Q

Hcg and AFP increase is suspicious for

A

Germ cell line origin malignancy

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11
Q

Reed sternberg cells

A

Classical Hodgkin lymphoma

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12
Q

Treatment of Hodgkin lymphoma (ABVD)

A

Doxorubicin, bleomycin, vinblastine, dacarbazine

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13
Q

DDx anterior mediastinal mass

A

Thymoma, thyroid, teratoma, lymphoma

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14
Q

CT scan radiation dose

A

8-12mSv

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15
Q

Anemia of chronic disease develops due to long term elevations in

A

Serum inflammatory cytokines

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16
Q

EGFR mutation manifests as

A

Adenocarcinoma of the lung

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17
Q

HER2 amplification manifests as

A

Breast and gastric cancers

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18
Q

RAS point mutations commonly manifest as

A

Metastatic colorectal cancer

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19
Q

BCR ABL translocation commonly manifests as

A

CML, ALL

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20
Q

BRAF point translocation commonly manifests as

A

Melanomas

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21
Q

JAK2 translocation often causes

A

Myeloproliferative disorders

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22
Q

MYC gene affected manifests as

A

Burritts lymphoma

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23
Q

Famililal adenomatous polYposis gene affected

A

APC

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24
Q

Li Fraumeni syndrome gene

A

P53

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25
Rb and P53 are examples of
Tumour suppressors
26
H pylori can cause what types of cancer
Gastric adenocarcinoma and MALT
27
ECOG scale ranges from
Asymptomatic to dead
28
ECOG of 3+ indicates
Usually systemic therapy wont be beneficial in metastatic cases
29
TACE in cancer treatment stands for
Transarterial chemoembolization
30
Mechanism behind most chemotherapy drugs
Inhibit mitosis, or induce DNA damage
31
Cyclophosphamide acts as what type of agent
Alkylating
32
Cisplatin acts as what type of agent
Intercalating
33
Etoposide acts as what kind of agent
Topoisomerase inhibiter
34
Doxorubicin and Epirubicin are what kind of drug
Anthracyclins in chemo
35
Methotrexate is a
Anti-folate, antimetabolite
36
Risk of cyclophosphamide and etoposide
Secondary malignancy
37
Risk of cisplatin
Nephrotoxic, ototoxic, neurotoxic
38
Risk of bleomycin
Pulmonary toxicity
39
Risk of methotrexate
Folic acid deficiency, hepatotoxicity
40
Tamoxifen is a
SERM
41
Treat neutropenia fever with
PIP TAZO (pseudomonas, candida, aspergillosis)
42
Neutropenia enterocolitis is a mucosal injury caused by
Chemotherapy
43
Hypersensitivity reactions can occur hours after administration of which two drugs used in oncology?
Paclitaxel, carboplatin
44
What types of cancers are more common in people with Down’s syndrome
ALL and AML
45
ALL blood smear shows
Blasts
46
Auer rods are characteristic of
AML
47
BCR ABL Philadelphia chromosome is seen in
CML
48
Reed sternberg cell characteristic of
Hodgkin lymphoma
49
Starry sky appearance to smear is seen in
Burritts lymphoma
50
Osteosarcoma and Ewing’s sarcoma present as
Pain and swelling in the bones of the appendicular skeleton
51
Treating spinal cord compression in oncology patients
Dexamethasone
52
Risk reducing surgery for BRCA
Mastectomy, salpingooophorectomy
53
Risk reducing surgery for FAP
colectomy
54
Risk reducing surgery for CDH1
Gastrectomy
55
Risk reducing surgery for HNPCC
Colectomy, hysterectomy
56
Risk reducing surgery for MEN2
Thyroidectomy
57
Most common adult leukemia
Acute myeloid leukemia
58
Cancer that can cause mediastinal mass, pancytopenia, and elevated LDH
Hodgkin lymphoma
59
Monoclonal proteins on electrophoresis is associated with what condition?
Multiple myeloma
60
Hyperplastic polyps located in the rectosigmoid colon have a prognosis that is
Completely benign
61
Adenomatous polyps prognosis
Dysplastic and can evolve into colon cancer
62
Sessile serrated polyps prognosis
Malignant potential
63
Women with PCOS are at increased risk of what malignancy?
Endometrial hyperplasia and cancer due to unopposed estrogen stimulation

Clerkship Prep (34 decks)

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