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Clerkship Prep > Oncology > Flashcards

Oncology Flashcards

1
Q

Smooth muscle cancer

A

Leiomyosarcoma

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2
Q

Skeletal muscle cancer

A

Rhabdomyosarcoma

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3
Q

Vessel cancer

A

ANGII sarcoma

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4
Q

TNM staging

A

T - tumour size
N - how many nodes
M - has it spread

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5
Q

NX cancer staging

A

Regional nodes cannot be assessed

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6
Q

N0 cancer staging

A

No regional lymph node mets

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7
Q

N1 cancer staging

A

Regional lymph node metastasis

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8
Q

Sarcomas (CT malignancies) often metastasize to

A

The lungs

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9
Q

LDH increase is suspicious for which cancer

A

Lymphoma

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10
Q

Hcg and AFP increase is suspicious for

A

Germ cell line origin malignancy

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11
Q

Reed sternberg cells

A

Classical Hodgkin lymphoma

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12
Q

Treatment of Hodgkin lymphoma (ABVD)

A

Doxorubicin, bleomycin, vinblastine, dacarbazine

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13
Q

DDx anterior mediastinal mass

A

Thymoma, thyroid, teratoma, lymphoma

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14
Q

CT scan radiation dose

A

8-12mSv

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15
Q

Anemia of chronic disease develops due to long term elevations in

A

Serum inflammatory cytokines

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16
Q

EGFR mutation manifests as

A

Adenocarcinoma of the lung

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17
Q

HER2 amplification manifests as

A

Breast and gastric cancers

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18
Q

RAS point mutations commonly manifest as

A

Metastatic colorectal cancer

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19
Q

BCR ABL translocation commonly manifests as

A

CML, ALL

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20
Q

BRAF point translocation commonly manifests as

A

Melanomas

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21
Q

JAK2 translocation often causes

A

Myeloproliferative disorders

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22
Q

MYC gene affected manifests as

A

Burritts lymphoma

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23
Q

Famililal adenomatous polYposis gene affected

A

APC

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24
Q

Li Fraumeni syndrome gene

A

P53

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25
Q

Rb and P53 are examples of

A

Tumour suppressors

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26
Q

H pylori can cause what types of cancer

A

Gastric adenocarcinoma and MALT

27
Q

ECOG scale ranges from

A

Asymptomatic to dead

28
Q

ECOG of 3+ indicates

A

Usually systemic therapy wont be beneficial in metastatic cases

29
Q

TACE in cancer treatment stands for

A

Transarterial chemoembolization

30
Q

Mechanism behind most chemotherapy drugs

A

Inhibit mitosis, or induce DNA damage

31
Q

Cyclophosphamide acts as what type of agent

A

Alkylating

32
Q

Cisplatin acts as what type of agent

A

Intercalating

33
Q

Etoposide acts as what kind of agent

A

Topoisomerase inhibiter

34
Q

Doxorubicin and Epirubicin are what kind of drug

A

Anthracyclins in chemo

35
Q

Methotrexate is a

A

Anti-folate, antimetabolite

36
Q

Risk of cyclophosphamide and etoposide

A

Secondary malignancy

37
Q

Risk of cisplatin

A

Nephrotoxic, ototoxic, neurotoxic

38
Q

Risk of bleomycin

A

Pulmonary toxicity

39
Q

Risk of methotrexate

A

Folic acid deficiency, hepatotoxicity

40
Q

Tamoxifen is a

A

SERM

41
Q

Treat neutropenia fever with

A

PIP TAZO (pseudomonas, candida, aspergillosis)

42
Q

Neutropenia enterocolitis is a mucosal injury caused by

A

Chemotherapy

43
Q

Hypersensitivity reactions can occur hours after administration of which two drugs used in oncology?

A

Paclitaxel, carboplatin

44
Q

What types of cancers are more common in people with Down’s syndrome

A

ALL and AML

45
Q

ALL blood smear shows

A

Blasts

46
Q

Auer rods are characteristic of

A

AML

47
Q

BCR ABL Philadelphia chromosome is seen in

A

CML

48
Q

Reed sternberg cell characteristic of

A

Hodgkin lymphoma

49
Q

Starry sky appearance to smear is seen in

A

Burritts lymphoma

50
Q

Osteosarcoma and Ewing’s sarcoma present as

A

Pain and swelling in the bones of the appendicular skeleton

51
Q

Treating spinal cord compression in oncology patients

A

Dexamethasone

52
Q

Risk reducing surgery for BRCA

A

Mastectomy, salpingooophorectomy

53
Q

Risk reducing surgery for FAP

A

colectomy

54
Q

Risk reducing surgery for CDH1

A

Gastrectomy

55
Q

Risk reducing surgery for HNPCC

A

Colectomy, hysterectomy

56
Q

Risk reducing surgery for MEN2

A

Thyroidectomy

57
Q

Most common adult leukemia

A

Acute myeloid leukemia

58
Q

Cancer that can cause mediastinal mass, pancytopenia, and elevated LDH

A

Hodgkin lymphoma

59
Q

Monoclonal proteins on electrophoresis is associated with what condition?

A

Multiple myeloma

60
Q

Hyperplastic polyps located in the rectosigmoid colon have a prognosis that is

A

Completely benign

61
Q

Adenomatous polyps prognosis

A

Dysplastic and can evolve into colon cancer

62
Q

Sessile serrated polyps prognosis

A

Malignant potential

63
Q

Women with PCOS are at increased risk of what malignancy?

A

Endometrial hyperplasia and cancer due to unopposed estrogen stimulation

Clerkship Prep (34 decks)

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