ONC Flashcards
0
Q
Bleomycin + Busulfan
A
Pulmonary Fibrosis
** Also Hyperpigmentation + SEVERE myelosuppression w Busulfan **
1
Q
Cancer Drugs ~GENERAL~
(S/E profile of most cancer drugs: 4)?
A
** BM, Skin, Hair, GI **
2
Q
Cisplatin
A
Nephrotoxicity / Ototoxicity
3
Q
Cyclophosphamide (3)
A
- SIADH
- Hemorrhagic Cystitis
- Bladder Ca
4
Q
Dauno- + Doxorubicin
A
Dilated Cardiomyopathy
5
Q
Hydroxyurea
A
GI upset
6
Q
Ifosfamide
A
Hemorrhagic Cystitis
* Prevent by co-administering MESNA *
7
Q
Methotrexate
(2)?
A
- Megaloblastic Anemia with hypersegmented neutrophils
- Interstitial fibrosis in Lungs
7
Q
Imatinib
A
Fluid retention
9
Q
Procarbazine
A
Disulfiram-like rx
9
Q
Prednisone / Prednisolone
A
Cushing-like s+s
10
Q
Nitrosoureas: -stine + Streptozocin
A
CNS toxicity
10
Q
Vemurafenib
A
Metastatic Melanoma
12
Q
Alkylating Chemotherapy
A
AML
13
Q
6-MPT
Metab, CI?
A
METAB = by Xanthine Oxidase.
CI:
- Allopurinol (inhibits XO)
