ANS Flashcards
Anti-Cholinesterase (AchE) Poisoning
Causes, Pres (“DUMBBELSS: Epi + 9), RX (2)?
Organophosphates (ie in Insecticides) irreversibly inhibit AchE.
PRES: Farmers. * “DUMBBELSS” *
- Diarrhea
- Urination
- Miosis
- Bronchospasm
- Bradycardia
- Excitation of CNS & Skel muscle
- Lacrimation
- Sweating
- Salivation
RX: (Person is too cholinergic therefore we must make them
ANTI-cholinergic ->
give them Anti-Cholinergics = Muscarinic Antagonists)
- Atropine
- Pralidoxime
Cholinomimetic Agents
(3)?
- Exacerbation of Asthma + COPD
- Peptic Ulcers
- Miosis + Cycloplasm
Atropine Toxicity
Pres (5), Comp (3, pop affected for each)?
“Hot as a hare, Dry as a bone, Red as a beet, Blind as a bat,
Mad as a hatter.”
PRES:
- ↑body temp (due to↓sweating)
- Dry skin & mouth, Urine retention & Constipation
- Flushed skin, Rapid pulse
- Cycloplegia
- Disorientation
COMP:
- Hyperthermia in infants
- Urine retention in men with BPH
- Acute Angle-Closure Glaucoma in elderly
a Agonists (Epi + Brimonidine)
(4)?
- Mydriasis
- Ocular hyperemia
- Blurry vision
- Allergic rxs + Pruritus
a1 Blockers / Antagonists
(2)?
- Orthostatic Hypotension (1st dose only)
- Headache + Dizziness
a2 Blockers / Antagonists (Mirtazapine)
(2)?
- Sedation (??)
- ↑appetite +↑Cholesterol
b Agonists
HYPOkalemia
b Blockers / Antagonists
CI, (5)?
** Use with caution in Diabetics (may mask signs of hypoglycemia) **
- HYPERkalemia
- Impotence
- CV: Bradycardia, CHF, AV Block
- Exacerbation of Asthma
- CNS: Sedation + Sleep alterations
Cocaine
(2)?
- Coronary vasospasm
- Arrhythmias
Methyldopa
Direct-Coombs+ Hemolytic Anemia
Metoprolol
Dyslipidemia
Phenoxybenzamine
(2)?
- Orthostatic Hypotension
- Reflex Tachycardia
Drug Class that causes Mydriasis (pupil dilation)?
a-Agonists (Epi + Brimonidine)
** Therefore CI in Closed-Angle Glaucoma **
Drug Classes that cause Miosis (pupil constriction)?
(2)?
- Cholinomimetics
- Opioid Analgesics
Drug Class that causes Miosis (pupil constriction) +
Cyclospasm (ciliary muscle contraction)?
Cholinomimetics
