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Drug Reactions > NEURO > Flashcards

NEURO Flashcards

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Organic Chemistry 101 flashcards
0
Q

Alzheimer’s Drugs

(4)?

A
  • Dizziness
  • Nausea: D, G + R
  • Insomnia: D, G + R
  • Confusion + Hallucinations: Memantine
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1
Q

Amantadine

A

Ataxia

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2
Q

Antipsychotics (2)

A
  • Parkinson-like Sx

- Tardive dyskinesia

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4
Q

Barbiturates

Pres (4), CI?

A

** Induces P450 and SLOWS things down. **

  • P450 drug interactions
  • Dependence
  • Additive CNS depression with alcohol
  • CV + Resp depression (can lead to death)

CI in Porphyria.

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5
Q

Benzodiazepines (-lam/pam) / Nonbenzo Hypnotics (Z Drugs)

Pres (3), RX for OD?

A

PRES:

  • ↓BP
  • Severe postop resp depression
  • Amnesia
  • Ataxia + Confusion + Headaches (Z drugs)

RX for OD = Flumazenil (competitive antagonist at GABA benzo receptor)

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6
Q

Brimonidine (3)

A
  • Blurry vision
  • Sensation of foreign object in eye
  • Ocular hyperemia + pruritus
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6
Q

Buproprion

A

Seizures

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8
Q

Carbamazepine (3)

A
  • Blood Dyscrasias (Agranulocytosis + Aplastic Anemia)
  • SIADH
  • Steven-Johnson Sx
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9
Q

DFH (CI: 2 Types of Generalized Seizures)

A
  • Myoclonic seizures

- Absence seizures

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10
Q

Clozapine

A

Agranulocytosis

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11
Q

Epilepsy Drugs (General / Common Toxicities) (7)

A
  • Tolerance + Dependence
  • Sedation
  • Ataxia
  • Diplopia
  • Steven-Johnson Sx
  • Induction of P450 + Liver Toxicity
  • Teratogenicity
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11
Q

Ethosuximide (3)

A
  • GI distress
  • Urticaria
  • Steven-Johnson Sx
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12
Q

Halothane

A

Hepatic necrosis

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14
Q

Lamotrigine

A

Steven-Johnson Sx

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15
Q

Latanoprost

A

Brown pigmentation of iris

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15
Q

Ketamine

A

Disorientation, Hallucinations + Nightmares

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15
Q

Levodopa (2)

A
  • Arrhythmias (due to peripheral conversion to dopamine)
  • Dyskinesia following admin (seen with long-term use) ;
    Akinesia b/w doses
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16
Q

Lithium (2)

A
  • Diabetes Insipidus

- Hypothyroidism (incl Myxedema)

18
Q

Local Anesthetics (-caine) (4)

A
  • CNS excitation
  • Arrhythmias (Cocaine)
  • Severe CV toxicity (Bupivacaine)
  • Hypertension / Hypotension
19
Q

Inhaled Anesthetics (-ane) (5)

A
  • Expansion of trapped gas (NO)
  • Proconvulsant (Enflurane)
  • Hepatotoxicity (Halothane)
  • Nephrotoxicity (Methoxyflurane)
  • Malignant Hyperthermia (all EXCEPT N2O)
20
Q

Opioid Analgesics

Pres (4), RX?

** Generally SLOW things down **

A

PRES: * Tolerance DOESN’T develop to miosis + constipation.*

  • Addiction
  • CNS + Resp depression (CNS depression additive w other drugs)
  • Miosis: “Pinpoint Pupils”
  • Constipation

RX:
- Naloxone or Naltrexone (opioid receptor antagonists)

21
Q

Phenobarbital

A

Rash / Stevens-Johnson Sx

22
Q

Phenytoin (5)

A
  • Nystagmus
    • Gingival Hyperplasia
  • Megaloblastic Anemia
  • Rash / SLE-like Sx / Stevens-Johnson Sx
    • Hirsutism
23
Q

Reserpine

A

Parkinson-like Sx

24
Q

Risperidone

A

Torsades de Pointes / Prolonged QT

25
Q

Selegilline

A
  • Can enhance adverse effects of L-dopa *
26
Q

Sumatriptan (2)

CI (2)?

A
  • Coronary vasospasm
  • Mild tingling

CI: patients with CAD or Prinzmetal’s Angina

27
Q

Topiramate (2)

A
  • Weight LOSS

- Kidney Stones

28
Q

Tramadol (3)

A
  • Opioid toxicity s+s
  • Serotonin Sx
  • Proconvulsant (↓seizure threshold)
29
Q

Valproic Acid (5)

A
  • Tremor
  • Weight GAIN
  • GI distress
  • Hepatic necrosis
  • Spina Bifida in fetus
30
Q

NON-DEPOLARIZING Neuromuscular Blocking Drugs (-cur-)

Reversal of Blockade with?

A

Anticholinesterases

31
Q

Succinylcholine: DEPOLARIZING Neuromuscular Blocking Drug (2)

Reversal of Blockade (Phase II = repol but blocked) with?

A
  • ↑K + Ca
  • Malignant Hyperthermia

Anticholinesterase (eg Neostigmine)

32
Q

Drugs that cause Cinchonism (2)?

A
  • Quinidine

- Quinine (anti-malarial)

33
Q

Drugs that cause Parkinson-like Sx (3)?

A
  • Antipsychotics
  • Reserpine
  • Metoclopramide
34
Q

Drugs that cause Red / Green Color-Blindness (2 Antibiotics)?

A
  • Amphoctericin B

- Ethambutol

35
Q

Drugs that cause Retinopathy

(2: 1 Antiprotozoan + 1 Antiviral Class)?

A
  • Chloroquine

- Viral Release Inhibitors (Zanamivir + Oseltamivir)

36
Q

Drug Class that causes Tardive Dyskinesia

A

Antipsychotics

37
Q

Drug Class that causes Visual Disturbances?

A

SERMs

38
Q

Drugs that cause Seizures (3: 1 Neuro + 2 Antibiotics)?

A
  • Bupropion
  • Imipenem / Cilastatin
  • Isoniazid (INH)
39
Q

Drugs that can cause Serotonin Sx

A
  • Linezolid
40
Q

NEUROTOXIC Drugs

Mech, General Pres (6), Drugs (7 Antibiotics)?

A

MECH = Lipid-soluble drugs => Cross BBB.

PRES:

  • Headaches
  • Dizziness / Ataxia
  • Confusion / Mental Status abnormalities
  • Sensory disturbances (incl vision problems)
  • Speech problems
  • Seizures

DRUGS:

  • Carbapenems
  • Fluoroquinolones
  • INH
  • Terbinafine
  • Griseofulvin
  • Amantadine
  • Efavirenz
41
Q

OTOTOXIC Drugs (2 Antibiotics)

A
  • Vancomycin

- Aminoglycosides

42
Q

Drugs that cause Acoustic Nerve Damage

A

Cis-/Carboplatin

43
Q

Drugs that cause Peripheral Neuropathy

A

Vincristine

Drug Reactions (15 decks)

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