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MSK Flashcards

1
Q

Aspirin and NSAIDs (3 COMMON)

A
  • Hemolysis in G6PD-deficient patients
  • Gastric Ulceration and Upper GI Bleeding
  • Interstitial Nephritis and Renal Ischemia / Acute Renal Failure
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2
Q

Aspirin (3 UNIQUE)

A
  • Resp Alkalosis (early) -> Mixed Resp Alkalosis/Metab Acidosis (late)
  • Reye Sx (PEDS)
  • Tinnitus
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3
Q

NSAIDs (3)?

A
  • Aplastic Anemia
  • Gastric Ulceration and Upper GI Bleeding (due to its PGE1 inhibition)
  • Interstitial Nephritis and Renal Ischemia / Acute Renal Failure
    (due to its PGE1 inhibition)
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4
Q

Acetaminophen

A

Hepatic Necrosis

Acetaminophen metabolite depletes Glutathione + forms toxic adducts in Liver

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5
Q

Allopurinol

CI?

A

Stevens-Johnson Sx

CI:
- Salicylates

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6
Q

Celecoxib (2)?

A
  • Sulfa allergy

- ↑risk of thrombosis

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7
Q

Colchicine (2)?

A
  • Agranulocytosis

- Myopathies

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7
Q

Bisphosphonates (2)?

A
  • Corrosive Esophagitis

- Osteonecrosis of Jaw

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8
Q

Corticosteroids (4: 1 msk + 3 heme)

A
  • Osteoporosis / Osteonecrosis (high-dose)
  • Neutrophilia (impair migration of neutrophils out of vasculature
    by↓activation of neutrophil adhesion molecules)
  • Eosinopenia (sequester eosinophils in lymph nodes)
  • Lymphopenia (cause apoptosis of lymphocytes)
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9
Q

Prednisone

A

Rhabdomyolysis

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10
Q

Probenecid (2)?

A
  • Uric acid calculi (inhib reabs of uric acid in PCT)

- Inhib secretion of Penicillin

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11
Q

TNF-a Inhibitors

A

Predispose to infection (ie reactivation of latent TB)

(Inhibiting TNF-a -> NO activation of Macrophages ->
NO degradation of phagocytosed microbes)

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12
Q

Drugs that cause Fat Redistribution (2)?

A
  • Glucocorticoids

- Protease Inhibitors

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13
Q

Drugs that cause Gingival Hyperplasia (2)?

A
  • Phenytoin

- Verapamil

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14
Q

Drugs that cause Gout (5)?

A
  • Cyclosporin
  • Niacin
  • Pyrazinamide
  • Furosemide
  • Thiazides
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15
Q

Drugs that cause Myopathies (8)?

A
  • Glucocorticoids
  • Fibrates
  • Niacin
  • Statins
  • Colchicine
  • Interferon-a
  • Penicillamine
  • Hydroxychloroquine
16
Q

Drugs that cause Osteoporosis (2)?

A
  • Corticosteroids

- Heparin

17
Q

Drugs that cause Photosensitivity (3: “SAT for a photo”)?

A
  • Sulfonamides
  • Amiodarone
  • Tetracycline
18
Q

Drugs that cause Rash (6: 4 Antibiotics + 2 Antivirals)?

A
  • Aminopenicillins
  • Carbapenems
  • Macrolides
  • Fluoroquinolones
  • Tenofovir
  • NNRTIs
19
Q

Drugs that cause Rash / Stevens-Johnson Sx

(8: “bad rash after a PEC SLAPP”)?

A
  • Penicillin
  • Ethosuximide
  • Carbamazepine
  • Sulfa drugs
  • Lamotrigine
  • Allopurinol
  • Phenytoin
  • Phenobarbital
20
Q

Drugs that cause Rhabdomyolysis

(5: “F RIPS”)?

A
  • Fibrates
  • Rifampin
  • INH
  • Prednisone
  • Statins
21
Q

Drug that causes Tendonitis / Tendon rupture +

Cartilage damage?

A

Fluoroquinolones

22
Q

Drugs that cause SLE-like sx (4)?

A
  • Hydralazine
  • Procainamide
  • Phenytoin
  • INH

Drug Reactions (15 decks)

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