MSK Flashcards
1
Q
Aspirin and NSAIDs (3 COMMON)
A
- Hemolysis in G6PD-deficient patients
- Gastric Ulceration and Upper GI Bleeding
- Interstitial Nephritis and Renal Ischemia / Acute Renal Failure
2
Q
Aspirin (3 UNIQUE)
A
- Resp Alkalosis (early) -> Mixed Resp Alkalosis/Metab Acidosis (late)
- Reye Sx (PEDS)
- Tinnitus
3
Q
NSAIDs (3)?
A
- Aplastic Anemia
- Gastric Ulceration and Upper GI Bleeding (due to its PGE1 inhibition)
- Interstitial Nephritis and Renal Ischemia / Acute Renal Failure
(due to its PGE1 inhibition)
4
Q
Acetaminophen
A
Hepatic Necrosis
Acetaminophen metabolite depletes Glutathione + forms toxic adducts in Liver
5
Q
Allopurinol
CI?
A
Stevens-Johnson Sx
CI:
- Salicylates
6
Q
Celecoxib (2)?
A
- Sulfa allergy
- ↑risk of thrombosis
7
Q
Colchicine (2)?
A
- Agranulocytosis
- Myopathies
7
Q
Bisphosphonates (2)?
A
- Corrosive Esophagitis
- Osteonecrosis of Jaw
8
Q
Corticosteroids (4: 1 msk + 3 heme)
A
- Osteoporosis / Osteonecrosis (high-dose)
- Neutrophilia (impair migration of neutrophils out of vasculature
by↓activation of neutrophil adhesion molecules) - Eosinopenia (sequester eosinophils in lymph nodes)
- Lymphopenia (cause apoptosis of lymphocytes)
9
Q
Prednisone
A
Rhabdomyolysis
10
Q
Probenecid (2)?
A
- Uric acid calculi (inhib reabs of uric acid in PCT)
- Inhib secretion of Penicillin
11
Q
TNF-a Inhibitors
A
Predispose to infection (ie reactivation of latent TB)
(Inhibiting TNF-a -> NO activation of Macrophages ->
NO degradation of phagocytosed microbes)
12
Q
Drugs that cause Fat Redistribution (2)?
A
- Glucocorticoids
- Protease Inhibitors
13
Q
Drugs that cause Gingival Hyperplasia (2)?
A
- Phenytoin
- Verapamil
14
Q
Drugs that cause Gout (5)?
A
- Cyclosporin
- Niacin
- Pyrazinamide
- Furosemide
- Thiazides
