IMMUNO Flashcards
0
Q
Tacrolimus (3)
A
- (Cyclosporin S/E)
- Gingivial Hyperplasia
- Hirsutism
1
Q
Cyclosporine (6)
A
- Predisposition to viral infections + lymphomas
- Neurotoxicity (ie peripheral neuropathy)
- Nephrotoxicity
- Htn
- Hyperglycemia
- Gout
2
Q
Sirolimus / Rapamycin (2)
A
- Thrombocytopenia + Leukopenia
* - Hyperlipidemia
3
Q
Azathioprine
CI?
A
(Active metabolite = mercaptopurine. Mercaptopurine metab by Xanthine Oxidase.)
CI:
- Allopurinol
4
Q
Muromonab-CD3 / OKT3
A
Cytokine-Release Sx
5
Q
Interferon-a
A
Myopathies
6
Q
Trastuzumab / Herceptin
A
Cardiotoxicity
7
Q
Natalizumab / Rituximab
A
↑risk of PML (esp in patients w JC virus)
8
Q
Thalidamide / Contergan
A
Phocomelia (full range of fetal devel problems)
9
Q
BCG Vaccine
Comp?
A
COMP:
- IL-12 receptor def (T-cell disorder)
10
Q
Rabies or Smallpox Vaccines
A
Acute Disseminated Encephalomyelitis
11
Q
Anti-TNF Drugs (Adalimu- + Infliximab, Etanercept, Thalidamide)
Precaution?
A
Granuloma B/D -> Disseminated dz.
PRECAUTION:
Test for Granulomatous Dz (eg latent TB) before starting.
