Obesity Flashcards

1
Q

What are the primary functions of adipose tissue?

A

It serves as a reservoir of readily convertible energy and serves
as a heat insulator.
Nagelhout JJ, Plaus KL. Nurse Anesthesia. 5th ed. St. Louis,
MO: Elsevier Saunders Company; 2014: 1051.

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2
Q

What is the formula for BMI?

A

BMI = (Weight in Kg)/(height in meters)(height in meters) which
is to say, it is the weight in kilograms divided by the height in
meters squared.
Nagelhout JJ, Plaus KL. Nurse Anesthesia. 5th ed. St. Louis,
MO: Elsevier Saunders Company; 2014: 1051.

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3
Q

What is the formula for ideal body weight?

A

Male ideal body weight in kilograms = height in centimeters -
100. The female ideal body weight in kilgrams = height in
centimeters - 105.
Barash PG, Cullen BF, Stoelting RK, Cahalan MK, Stock MC,
Ortega R. Clinical Anesthesia. 7th ed. Philadelphia, PA:
Lippincott Williams and Wilkins; 2013: 1275.

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4
Q

What are the classifications of obesity based on BMI?

A

A BMI < 18.5 = Underweight, 18.5-24.9 = Normal, 25-29.9
= Overweight, 30-34.9 = Obesity Class I, 35-39.9 = Obesity
Class II, > 40 = Obesity Class III (morbid obesity)
Nagelhout JJ, Plaus KL. Nurse Anesthesia. 5th ed. St. Louis,
MO: Elsevier Saunders Company; 2014: 1051.

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5
Q

What is gynecoid obesity?

A

Gynecoid obesity, also called peripheral obesity, is the
deposition of fat primarily in the hips, buttocks, and thighs.
Barash PG, Cullen BF, Stoelting RK, Cahalan MK, Stock MC,
Ortega R. Clinical Anesthesia. 7th ed. Philadelphia, PA:
Lippincott Williams and Wilkins; 2013: 1275.

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6
Q

What is android obesity?

A

Android obesity, also called central obesity, is the deposition of
fat primarily in the upper body. Compared to gynecoid obesity,
it has a higher associated risk for cardiovascular disease.
Barash PG, Cullen BF, Stoelting RK, Cahalan MK, Stock MC,
Ortega R. Clinical Anesthesia. 7th ed. Philadelphia, PA:
Lippincott Williams and Wilkins; 2013: 1275.

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7
Q

How does obesity affect the choice of anesthetic?

A

No difference has been demonstrated in emergence following
inhalation versus narcotic techniques. Many clinicians,
however, recommend a ‘light’ general anesthetic combined with
epidural anesthesia whenever possible as it reduces the need
for opioids and facilitates coughing and deep breathing after
surgery.
Nagelhout JJ, Plaus KL. Nurse Anesthesia. 5th ed. St. Louis,
MO: Elsevier Saunders Company; 2014: 1063.

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8
Q

How should positioning for induction of an obese

patient be carried out?

A

The patient should have the shoulders and head ramped up
with the head in sniffing position and the bed should be placed
in reverse Trendelenburg to increase the FRC and allow large
breasts to fall away from the neck. The acronym HELP may be
used to remember ‘Head Elevated Laryngoscopy Position’ for
obese patients.
Nagelhout JJ, Plaus KL. Nurse Anesthesia. 5th ed. St. Louis,
MO: Elsevier Saunders Company; 2014: 1061-1062.

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9
Q

What measurable characteristic best predicts the
occurrence of a difficult airway in the obese patient?
What factors are present in the obese airway that
may result in a difficult airway?

A

Neck circumference is the single best predictor of a difficult
airway. A neck circumference of 40 cm is associated with a 5%
chance of difficult intubation while a neck circumference of 60
cm indicates a 35% chance of difficult intubation. Fat rolls
around the neck restrict neck motion while fat in the airway
tissue decreases the glottic opening. Other anatomic
abnormalities that are often associated with obesity include
reduced temporomandibular and atlantoaxial motion.
Nagelhout JJ, Plaus KL. Nurse Anesthesia. 5th ed. St. Louis,
MO: Elsevier Saunders Company; 2014: 1060.

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10
Q

What are the risks particular to obese patients

presenting for bariatric surgery?

A

Third-space losses generally exceed blood loss for bariatric
procedures. At least one large-bore IV should be started and
the patient should be typed and crossed for two units of
PRBCs. IV fluids should be warmed and an estimated 10-15
mL/kg/hour of lactated ringer s solution or normal saline should
be administered. The most important anesthetic considerations
for bariatric surgery often has more to do with the patient class
than the procedure itself. Morbidly obese patients have higher
morbidity and mortality rates. They have a higher risk for sleep
apnea, decreased chest wall compliance (but normal lung
compliance), reduced expiratory reserve volume and reduced
functional residual capacity. Hypertension is common in these
patients and blood volume and cardiac output increase to
maintain blood flow to the increased adipose tissue. Left
ventricular dysfunction may be present, making it difficult for the
patient to tolerate increases in blood volume or cardiac
depression. Diabetes mellitus is often present and fatty
infiltration of the liver can lead to altered metabolism and
unpredictably prolonged drug actions.
Jaffe RA, Samuels SI. Anesthesiologist’s Manual of Surgical
Procedures. 4th ed. Philadelphia, PA: Lippincott Williams and
Wilkins, 2009: 603.

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11
Q

Should obese patients undergo rapid-sequence

induction?

A

Obese patients are assumed to have a full-stomach and at risk
for pulmonary aspiration. Because of this, it is generally
accepted that patients up to a BMI of 50 should undergo rapid
sequence induction with cricoid pressure. Some clinicians
postulate that because of the incidence of difficult airway,
patients above a BMI of 50 should undergo awake intubation.
Nagelhout JJ, Plaus KL. Nurse Anesthesia. 5th ed. St. Louis,
MO: Elsevier Saunders Company; 2014: 1061.

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12
Q

What parameters should be used to calculate drug

dosing in obese individuals?

A

Drugs that are distributed mainly to lean tissue should be dosed
according to lean body weight. Drugs that are even distributed
to lean and adipose tissue should be dosed according to total
body weight.
Barash PG, Cullen BF, Stoelting RK, Cahalan MK, Stock MC,
Ortega R. Clinical Anesthesia. 7th ed. Philadelphia, PA:
Lippincott Williams and Wilkins; 2013: 1281.

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13
Q

Name two anesthetic drugs that should be dosed

according to total body weight in the obese individual.

A

Succinylcholine and dexmedetomidine
Barash PG, Cullen BF, Stoelting RK, Cahalan MK, Stock MC,
Ortega R. Clinical Anesthesia. 7th ed. Philadelphia, PA:
Lippincott Williams and Wilkins; 2013: 1282.

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14
Q

How is the volume of distribution and elimination halflife
of midazolam compare between obese and nonobese
patients?

A

Both the volume of distribution and the elimination half-life are
significantly increased in obese patients, resulting in prolonged
duration of action in obese patients. A single intravenous dose
should be based on total body weight, but a continuous infusion
should be based on lean body weight.
Longnecker DE, Newman MF, Brown DL, Zapol WM.
Anesthesiology. 2nd ed. New York: McGraw-Hill; 2012: 309.

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15
Q

How should the local anesthetic dose for epidural

anesthesia be adjusted for an obese individual?

A

Due to fatty infiltration and vascular engorgement of the
epidural space, the level and onset of an epidural block can be
unpredictable. It is recommended that the local anesthetic dose
be reduced by 20% of that of a non-obese patient.
Lee CY. Manual of Anesthesiology. Singapore: McGraw-Hill;
2006: 261.

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16
Q

What diagnostic parameter is the most sensitive
indicator of the effect of obesity on pulmonary
function?

A

Obesity decreases respiratory compliance due to the
accumulation of fat on the chest wall, diaphragm, and abdomen
resulting in a decrease in functional residual capacity, vital
capacity, and total lung capacity. The reduction in functional
residual capacity is due to a reduction in the expiratory reserve
volume, which is the most sensitive indicator of the effect of
obesity on pulmonary function.
Longnecker DE, Newman MF, Brown DL, Zapol WM.
Anesthesiology. 2nd ed. New York: McGraw-Hill; 2012: 301-
303.

17
Q

How does the degree of obesity and the risk of

pulmonary aspiration correlate?

A

An increase in the BMI by 3.5 increases the risk for pulmonary
aspiration by 270%.
Longnecker DE, Newman MF, Brown DL, Zapol WM.
Anesthesiology. 2nd ed. New York: McGraw-Hill; 2012: 81.

18
Q

How does obesity affect the left ventricle?

A

Patients with morbid obesity have a larger total blood volume
than non-obese patients to supply the excess adipose tissue.
The excess blood volume and resulting increase in preload
causes ventricular dilation and increased left ventricular wall
stress (eccentric hypertrophy).
Longnecker DE, Newman MF, Brown DL, Zapol WM.
Anesthesiology. 2nd ed. New York: McGraw-Hill; 2012: 305.

19
Q

What is the incidence of obstructive sleep apnea in
obese patients? How does it affect cardiovascular
status?

A

Patients with obstructive sleep apnea typically develop
hypercarbia, polycythemia (not anemia), pulmonary
hypertension, and right-sided heart failure as a result.
Butterworth JF, Mackey DC, Wasnick JD. Morgan & Mikhail’s
Clinical Anesthesiology. 5th ed. New York, NY: McGraw-Hill;
2013: 741.

20
Q

How does obesity affect chest wall compliance?

A

Compression of abdominal, diaphragmatic, and thoracic
structures by adipose tissue results in thoracic kyphosis, lumbar
lordosis, and fixation of the thorax in an inspiratory position
which results in a decrease in chest wall compliance by about
35%.
Nagelhout JJ, Plaus KL. Nurse Anesthesia. 5th ed. St. Louis,
MO: Elsevier Saunders Company; 2014: 1053.

21
Q

How does obesity affect lung volumes?

A

Obesity results in a decrease in lung inflation. The FRC is
decreased to less than closing capacity. The expiratory reserve
volume, vital capacity and total lung capacity are also
decreased.
Nagelhout JJ, Plaus KL. Nurse Anesthesia. 5th ed. St. Louis,
MO: Elsevier Saunders Company; 2014: 1053.

22
Q

What are the gastrointestinal considerations in the

obese patient?

A

The risk of GERD, cholelithiasis, and pancreatitis are
substantially increased in the obese patient. Nonalcoholic fatty
liver disease, which consists of steatosis, cirrhosis,
hepatomegaly, abnormal liver enzyme levels, and impaired liver
function may be present. The mortality rate of cirrhosis is
approximately twice that in obese patients compared to normal
weight patients.
Nagelhout JJ, Plaus KL. Nurse Anesthesia. 5th ed. St. Louis,
MO: Elsevier Saunders Company; 2014: 1055.

23
Q

Why do liver enzymes tend to be elevated in patients

with morbid obesity?

A

Morbid obesity produces fatty infiltration, inflammation, and
necrosis of the liver. Abnormal liver function tests are present
in about 1/3 of morbidly obese individuals. Clearance of drugs is
usually not reduced, however. Increased alanine
aminotransferase is the most common abnormality.
Longnecker DE, Newman MF, Brown DL, Zapol WM.
Anesthesiology. 2nd ed. New York: McGraw-Hill; 2012: 306.

24
Q

What ECG changes are often seen in obese

patients?

A

Low QRS voltage, LVH criteria, left atrial enlargment, t-wave
flattening in the inferior and lateral leads, and prolonged QT
interval.
Nagelhout JJ, Plaus KL. Nurse Anesthesia. 5th ed. St. Louis,
MO: Elsevier Saunders Company; 2014: 1059-1060.

25
Q

How does obesity affect renal function?

A

Obesity is characterized by an increased glomerular filtration
rate, increased renal tubular resorption, and impaired sodium
excretion which further worsens hypertension.
Barash PG, Cullen BF, Stoelting RK, Cahalan MK, Stock MC,
Ortega R. Clinical Anesthesia. 7th ed. Philadelphia, PA:
Lippincott Williams and Wilkins; 2013: 1280.

26
Q

What are the principal cardiovascular considerations

of obesity?

A

The morbidity and mortality in obese patients centers around
cardiovascular disease in the form of ischemic heart disease,
hypertension, and heart failure. The formation and
maintenance of the extra adipose mass requires an extra 0.1
L/min of cardiac output for each additional kilogram of fat.
Chronic respiratory insufficiency results in a compensatory
increase in blood volume. The increased workload results in
increased oxygen consumption and carbon dioxide production,
increased left ventricular pressure and hypertrophy.
Hypertension is more than twice as common in obese patients.
Hypercholesterolemia is usually present. Arrhythmias occur as
a result of hypoxemia, sleep apnea, electrolyte disorders,
ventricular hypertrophy, and CAD.
Nagelhout JJ, Plaus KL. Nurse Anesthesia. 5th ed. St. Louis,
MO: Elsevier Saunders Company; 2014: 1052-1053.

27
Q

How does obesity hypoventilation syndrome (OHS)

differ from obstructive sleep apnea (OSA)?

A

Obesity hyperventilation syndrome is equally common among
males and females, exhibits an awake PaCO2 that is at least 45
mmHg, exhibits pulmonary hypertension that is more common
and more severe than that seen with obstructive sleep apnea,
and doesn’t exhibit nocturnal airway obstruction unless
concomitant OSA is present. Obstructive sleep apnea exhibits
a normal awake PaCO2 that increases during sleep-induced
obstruction, can exhibit pulmonary hypertension but is less
common than OHS, and occurs more frequently in males than
females.
Barash PG, Cullen BF, Stoelting RK, Cahalan MK, Stock MC,
Ortega R. Clinical Anesthesia. 7th ed. Philadelphia, PA:
Lippincott Williams and Wilkins; 2013: 595.

28
Q

How does obesity hypoventilation syndrome differ
from the respiratory changes associated with simple
obesity?

A

With simple obesity, the PaCO2, pH, and pulmonary
compliance are still in the range of normal values. OHS is
present when the morbidly obese patient exhibits inappropriate
somnolence, sleep apnea, hypoxemia, hypercapnia, and
decreased alveolar ventilation. Polycythemia, enlarged heart,
and cyanosis may also be present.
Nagelhout JJ, Plaus KL. Nurse Anesthesia. 5th ed. St. Louis,
MO: Elsevier Saunders Company; 2014: 1055.

29
Q

How does hyperinsulinemia contribute to

cardiovascular disease in the obese patient?

A

Hyperinsulinemia activates the sympathetic nervous system,
causes sodium retention, and results in an overall 50-60%
increase in the incidence of hypertension. The chronic
hypertension leads to concentric left ventricular hypertrophy and
an increase in the risk for congestive heart failure.
Hines RL, Marschall KE. Anesthesia & Co-Existing Diseases.
6th ed. Philadelphia, PA: Elsevier-Saunders; 2012: 318.