Glycolysis Flashcards

1
Q

What type of reaction is catalyzed by

phosphofructokinase?

A

Phosphoryl transfer
Guyton AC, & Hall, JE. Textbook of Medical Physiology. 12th
ed. Philadelphia: Saunders; 2011: 813-817.

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2
Q

Where does the citric acid cycle take place?

A

The citric acid cycle (Krebs’ cycle) occurs within the
mitochondria of eukaryotic cells.
Guyton AC, & Hall, JE. Textbook of Medical Physiology. 12th
ed. Philadelphia: Saunders; 2011: 813-817.

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3
Q

How many turns of the Krebs cycle does it take to

completely oxidize 1 glucose?

A

Two turns since glycolysis normally produces 2 pyruvate.
Guyton AC, & Hall, JE. Textbook of Medical Physiology. 12th
ed. Philadelphia: Saunders; 2011: 813-817.

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4
Q

What must be present for both the Krebs cycle and

the electron transport system to function?

A

Oxygen
Guyton AC, & Hall, JE. Textbook of Medical Physiology. 12th
ed. Philadelphia: Saunders; 2011: 813-817.

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5
Q

What is the maximum number of ATPs you can get

from 1 mole of glucose?

A

38
Guyton AC, & Hall, JE. Textbook of Medical Physiology. 12th
ed. Philadelphia: Saunders; 2011: 813-817.

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6
Q

Where does the Krebs cycle and the electron

transport reactions occur?

A

In the mitochondria
Guyton AC, & Hall, JE. Textbook of Medical Physiology. 12th
ed. Philadelphia: Saunders; 2011: 813-817.

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7
Q

Excluding any products of glycolysis or the electron
transport system, what are the final products of a
single turn of the Krebs cycle?

A

4 NADH, 1 FADH, and 1 ATP.
Guyton AC, & Hall, JE. Textbook of Medical Physiology. 12th
ed. Philadelphia: Saunders; 2011: 813-817.

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8
Q

If the electron transport system isn’t working, how
many ATPs can glycolysis and the Krebs cycle
produce?

A

4 ATP
Guyton AC, & Hall, JE. Textbook of Medical Physiology. 12th
ed. Philadelphia: Saunders; 2011: 813-817.

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9
Q

If glycolysis is working correctly and the Krebs cycle
and electron transport system are not used, what are
the final products produced?

A

2 ATP, 2 NADH, and 2 Pyruvate
Guyton AC, & Hall, JE. Textbook of Medical Physiology. 12th
ed. Philadelphia: Saunders; 2011: 813-817.

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10
Q

What type of reaction is catalyzed by glyceraldehyde-

3 phosphate dehydrogenase?

A

Phosphoryl transfer
Guyton AC, & Hall, JE. Textbook of Medical Physiology. 12th
ed. Philadelphia: Saunders; 2011: 813-817.

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11
Q

What type of reaction is catalyzed by

phosphoglucose isomerase?

A

Isomerization
Guyton AC, & Hall, JE. Textbook of Medical Physiology. 12th
ed. Philadelphia: Saunders; 2011: 813-817.

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12
Q

What type of reaction is catalyzed by

phosphoglycerate kinase?

A

Phosphoryl transfer
Guyton AC, & Hall, JE. Textbook of Medical Physiology. 12th
ed. Philadelphia: Saunders; 2011: 813-817.

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13
Q

What is the starting product for the Kreb’s cycle and

what compound is necessary for its formation?

A

AcetylCoA which is formed from pyruvate.
Guyton AC, & Hall, JE. Textbook of Medical Physiology. 12th
ed. Philadelphia: Saunders; 2011: 813-817.

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14
Q

What type of reaction is catalyzed by hexokinase?

A

Phosphoryl transfer
Guyton AC, & Hall, JE. Textbook of Medical Physiology. 12th
ed. Philadelphia: Saunders; 2011: 813-817.

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15
Q

What is oxidative phosphorylation?

A

Oxidative phosphorylation describes a series of electron
transfers that lead to the formation of adenosine triphosphate.
Oxidative phosphorylation is responsible for about 90% of all
oxygen consumed in the body.
Guyton AC, & Hall, JE. Textbook of Medical Physiology. 12th
ed. Philadelphia: Saunders; 2011: 813-817.

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16
Q

What type of reaction is catalyzed by pyruvate

kinase?

A

Phosphoryl transfer
Guyton AC, & Hall, JE. Textbook of Medical Physiology. 12th
ed. Philadelphia: Saunders; 2011: 813-817.

17
Q

What type of reaction is catalyzed by aldolase?

A

Aldol cleavage
Guyton AC, & Hall, JE. Textbook of Medical Physiology. 12th
ed. Philadelphia: Saunders; 2011: 813-817

18
Q

What type of reaction is catalyzed by enolase?

A

Dehydration
Guyton AC, & Hall, JE. Textbook of Medical Physiology. 12th
ed. Philadelphia: Saunders; 2011: 813-817.

19
Q

What type of reaction is catalyzed by

phosphoglycerate mutase?

A

phosphoryl shift
Guyton AC, & Hall, JE. Textbook of Medical Physiology. 12th
ed. Philadelphia: Saunders; 2011: 813-817.

20
Q

What is a phosphoryl shift reaction?

A

A reaction in which a phosphoryl group is shifted from one
oxygen atom to another within a molecule by a mutase.
Guyton AC, & Hall, JE. Textbook of Medical Physiology. 12th
ed. Philadelphia: Saunders; 2011: 813-817.

21
Q

How many ATP will one NADH generate?

A

3 ATP
Guyton AC, & Hall, JE. Textbook of Medical Physiology. 12th
ed. Philadelphia: Saunders; 2011: 813-817.

22
Q

What type of reaction is catalyzed by triose

phosphate isomerase?

A

Isomerization
Guyton AC, & Hall, JE. Textbook of Medical Physiology. 12th
ed. Philadelphia: Saunders; 2011: 813-817.

23
Q
What two enzyme reactions in glycolysis require ATP
to function (meaning that they use up ATP)?
A

Hexokinase and phosphofructokinase
Guyton AC, & Hall, JE. Textbook of Medical Physiology. 12th
ed. Philadelphia: Saunders; 2011: 813-817.

24
Q

What is an isomerization reaction?

A

A reaction involving the conversion of a ketose to an aldose, or
vice versa, by an isomerase.
Guyton AC, & Hall, JE. Textbook of Medical Physiology. 12th
ed. Philadelphia: Saunders; 2011: 813-817.

25
Q

What is a phosphoryl transfer reaction?

A

A reaction in which a phosphoryl group is transferred from ATP
to a glycolytic intermediate, or from the intermediate to ADP by
a kinase. Note: dehydrogenase also is a phosphoryl transfer
even though it doesn’t end in kinase.
Guyton AC, & Hall, JE. Textbook of Medical Physiology. 12th
ed. Philadelphia: Saunders; 2011: 813-817.

26
Q

What two enzyme reactions in glycolysis are

responsible for generating ATP?

A

Phosphoglycerate kinase and pyruvate kinase
Guyton AC, & Hall, JE. Textbook of Medical Physiology. 12th
ed. Philadelphia: Saunders; 2011: 813-817.

27
Q

What is a dehydration reaction?

A

A reaction involving the removal of water by a dehydratase.
(Enolase)
Guyton AC, & Hall, JE. Textbook of Medical Physiology. 12th
ed. Philadelphia: Saunders; 2011: 813-817.

28
Q

How many ATP does a single FADH produce?

A

2 ATP
Guyton AC, & Hall, JE. Textbook of Medical Physiology. 12th
ed. Philadelphia: Saunders; 2011: 813-817.