Nucleotide Biosynthesis Flashcards
what are the 2 pathways for nucleotide biosynthesis
de novo and salvage
what is the important molecule for the denovo and salvage pathway
5 phosphoribosyl 1 pyrophosphate (PRPP)
What 3 things are required for purine syntheis
tetra hydrofolate aspartate glycine co2
what is the form of the first purine ring
IMP
What is the base of the IMP
Hypoxathnine
what is the energy source regquired for IMP to AMP
gtp
what is the energy source required from IMP to GMP
atp
what is enzyme for IMP to AMP
adenylosuccinate synthetase
what isthe enzyme for IMP to GMP
IMP dehydrogenase
descriebe how we get PRPP
Ribose 5 phosphate with PRPP Sythetase enzyme
how we get IMP
PRPP + propp amidotransferase enzyme
what is the main regulator enzyme for pytiidine biosyntheis
carbomyl phosphate synthetase II
How many ATP needed for pyrimidine biosyntheis
2
what amino acind is needed for pyrimidine biosynthesis
aspartate
deoxyribonucleotides are synthesized from corresponding …
ribonucleotides
what enzyme is used to convert ribo into deoxy
ribonucleotide reductase
what from much nucleotides be in for them to turn into dioxyribnucletides
nucleotides must be in the diphosphate form
dUMP is converterd to dTMP via
thymidylate synthase
what are the 2 key transerase ezymes in the salvage of purines
adenosine phophoribosyltransferese APRT
Hypoxanthine guanine Phoprivosyltranserase HGPRT
What enzyme converts xanthine to uric acid
xanthine oxidase
what enzyme converts adenosine to inosine
adenosine deaminase
increased breakdown of purine cause
gout
what is the treatment for gout how does it work
allopurinol , inhibits xanthine oxidase
SICD- sever combined immunodeficieny is a deficieny in which enzyme
adenosine deaminase
Leshch nhyhan syndrome is a deficeincy in what enzyme
HGPRT deficiency
a deficiency in the catabolism of pyrimidines causes
ocotic aciduria
