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Meharry Biochem > Nucleotide Biosynthesis > Flashcards

Nucleotide Biosynthesis Flashcards

1
Q

what are the 2 pathways for nucleotide biosynthesis

A

de novo and salvage

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2
Q

what is the important molecule for the denovo and salvage pathway

A

5 phosphoribosyl 1 pyrophosphate (PRPP)

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3
Q

What 3 things are required for purine syntheis

A

tetra hydrofolate aspartate glycine co2

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4
Q

what is the form of the first purine ring

A

IMP

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5
Q

What is the base of the IMP

A

Hypoxathnine

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6
Q

what is the energy source regquired for IMP to AMP

A

gtp

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7
Q

what is the energy source required from IMP to GMP

A

atp

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8
Q

what is enzyme for IMP to AMP

A

adenylosuccinate synthetase

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9
Q

what isthe enzyme for IMP to GMP

A

IMP dehydrogenase

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10
Q

descriebe how we get PRPP

A

Ribose 5 phosphate with PRPP Sythetase enzyme

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11
Q

how we get IMP

A

PRPP + propp amidotransferase enzyme

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12
Q

what is the main regulator enzyme for pytiidine biosyntheis

A

carbomyl phosphate synthetase II

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13
Q

How many ATP needed for pyrimidine biosyntheis

A

2

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14
Q

what amino acind is needed for pyrimidine biosynthesis

A

aspartate

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15
Q

deoxyribonucleotides are synthesized from corresponding …

A

ribonucleotides

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16
Q

what enzyme is used to convert ribo into deoxy

A

ribonucleotide reductase

17
Q

what from much nucleotides be in for them to turn into dioxyribnucletides

A

nucleotides must be in the diphosphate form

18
Q

dUMP is converterd to dTMP via

A

thymidylate synthase

19
Q

what are the 2 key transerase ezymes in the salvage of purines

A

adenosine phophoribosyltransferese APRT

Hypoxanthine guanine Phoprivosyltranserase HGPRT

20
Q

What enzyme converts xanthine to uric acid

A

xanthine oxidase

21
Q

what enzyme converts adenosine to inosine

A

adenosine deaminase

22
Q

increased breakdown of purine cause

A

gout

23
Q

what is the treatment for gout how does it work

A

allopurinol , inhibits xanthine oxidase

24
Q

SICD- sever combined immunodeficieny is a deficieny in which enzyme

A

adenosine deaminase

25
Q

Leshch nhyhan syndrome is a deficeincy in what enzyme

A

HGPRT deficiency

26
Q

a deficiency in the catabolism of pyrimidines causes

A

ocotic aciduria

Meharry Biochem (17 decks)

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