Gluconeogenesis

Question 1

what is the overall idea of gluconeogenesis

Answer 1

making glucose from non carbohydrate precursers

Question 2

what is the starting and ending material in gluconeognensi

Answer 2

pyruvate to glucose

Question 3

t/f gluconeogenesis is a reversal of glycolysis

Answer 3

false, it is not

Question 4

where does gluconeogenesis occur

Answer 4

in the liver

Question 5

What is the first bipass used in gluconeogneeis

Answer 5

going from pyruvate to phosphoenol pyruvate use pyruvate carboxylase

Question 6

The atp required for the synthesis of glucose mainly comes from where

Answer 6

oxidation of fatty acids

Question 7

how many ATP and gtp are needed for gluconeogeneisis

Answer 7

4 atp and 2 gtp

Question 8

can mammals convert fatty acids to sugars

Answer 8

no!!! the product of fatty acid degradation is acetyl coa . you cannon have a conversino of acetly coa to oxalocaceteate

Question 9

what process is likely happening while gluconeogeneis is occuing

Answer 9

beta oxidaiton

Question 10

how many molecules of pyruvate are needed to make 1 molecule of glucose

Answer 10

2

Question 11

what is the name of the pathway that is active during exercise to make glucose

Answer 11

Cori cycle

Question 12

what are the only 2 nonglucogenic amino acids

Answer 12

leucine and lysine

Question 13

what are the 2 ketogenic amino acids

Answer 13

leucine and lysine

Question 14

t/f acetyl coa can be converted into glucose

Answer 14

false, bc will not convert to oxaloacetate

Question 15

t/f only even number fatty acids can be broken down into glucose

Answer 15

false!!! only odd number

Question 16

what is a negative regulator of fructose 1-6 bisphosphotase

Answer 16

fructose 2,6, bp

Question 17

what is a negative regulator of glycoltic intermediate of gluconeogeneis but not a glycolytic intermediate

Answer 17

fructose 2-6 bp

Question 18

describe the regulation of F 2,6 BP on glycolysis and gluconeogeneis

Answer 18

+ for glycolysis
- for gluconeogenesis

remember this is only a regulaory enzyme!

Question 19

Fructose 2-6 BP promotes________ and inhibits ________

Answer 19

glycolysis , gluconeogenesis

Question 20

does phosphorylaiton activate or inactivate PFK 2

Answer 20

inactivate which inhibits glycolysis and activates gluconeogeneis

Question 21

does dephosphorylation of PF2 activate glycolysis ?

Answer 21

yes! when dephosphorylated glycolysis is stimulated and gluconeogenesis is inhibited

Question 22

what are 4 precursers for gluconeogeneis

Answer 22

1. lactate (cori cycle)
2. glucogenic amino acids
3. glycerol
4. propanoate ( from odd chain fatty acid)

Question 23

what 2 enzymes are reciprocally regulated

Answer 23

Phosphofructokinase and fructose 1,6 bisphosphotase

pyruvate kinase and pyruvate carboxylase