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RUSVM Anesthesiology 2016 > NSAIDs > Flashcards

NSAIDs Flashcards

1
Q

What are the effects of NSAIDs?

A

Analgesia
Anti-inflammatory
antipyretic

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2
Q

What is the clinical use of NSAIDs?

A

Mild to moderate post OP pain

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3
Q

Mechanism of action for NSAIDs?

A

Both COX and LOX inhibition

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4
Q

What is COX-1 important for normal function of?

A

GI tract
Platelets
Kidneys

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5
Q

Main side effects of NSAIDs

A 
Ulceration 
perforation 
vomiting
diarrhea
hemostatic abnormality 
Renal impairment 
Hepatotoxicity 
Impairment of cartilage synthesis
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6
Q

Contraindication of NSAIDs

A 
Hypovolemia
hypotension 
Kidney disease
Hemostatic abnormality 
Pregnancy 
Concomitant glucocorticoid therapy
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7
Q

What is used for cats for chronic treatment?

A

Meloxicam

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8
Q

Carprofen

A

COX-2 inhibitor

Not approved for cats

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9
Q

Robenacoxib

A

Selective COX-2 inhibitor

Minimal side effects

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10
Q

Phenylbutazone

A

Non-selective COX inhibitor

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11
Q

What are the side effects of Phenylbutazone

A

GI ulceration

nephrotoxicity

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12
Q

Flunixin meglumine

A

Non-selective COX inhibitor for horses and cattle

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13
Q

Ketoprofen

A

Non-selective COX inhibitor

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14
Q

What are the side effects of Ketoprofen

A

Hemostatic abnormality
Adverse GI effects
used in horses

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15
Q

Acetylsalicylic acid

A

Non selective COX inhibitor

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16
Q

What are some side effects of Acetylsalicylic acid?

A

GI effects

Hemostatic abnormality

17
Q

What is another use of Aspirin in cats?

A

Antithrombotic agent

18
Q

What is toxic in cats and causes methemoglobinemia?

A

Acetominophen

RUSVM Anesthesiology 2016 (38 decks)

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